Prediction model for transformation of chronic atrophic gastritis to high-grade intraepithelial neoplasia based on traditional Chinese medicine syndrome patterns.
10.3724/zdxbyxb-2024-0542
- Author:
Xiangying LIN
1
,
2
;
Jingyao SHI
3
;
Xiaoyan HUANG
4
;
Zeyu ZHENG
4
;
Xiaofeng HUANG
4
;
Minghan HUANG
2
,
5
Author Information
1. Research Base of Traditional Chinese Medicine Syndrome, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China. linxiangyings@
2. com.
3. Department of Gastroenterology, People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou 350104, China.
4. Department of Gastroenterology and Hepatology, the Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou 350003, China.
5. Department of Gastroenterology and Hepatology, the Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou 350003, China. huangminghan2010@
- Publication Type:Journal Article
- Keywords:
Clinical study;
High-grade intraepithelial neoplasia;
Prediction model;
Risk factors;
Syndrome of static blood in stomach collaterals;
Traditional Chinese medicine syndrome
- MeSH:
Humans;
Gastritis, Atrophic/diagnosis*;
Medicine, Chinese Traditional;
Retrospective Studies;
Female;
Male;
Middle Aged;
Stomach Neoplasms/diagnosis*;
Adult;
Risk Factors;
Carcinoma in Situ/diagnosis*;
Aged;
Nomograms;
Chronic Disease;
Logistic Models
- From:
Journal of Zhejiang University. Medical sciences
2025;54(3):297-306
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To develop a risk prediction model for the transformation of chronic atrophic gastritis to high-grade intraepithelial neoplasia (HGIN) based on traditional Chinese medicine (TCM) syndrome patterns.
METHODS:Clinical data of 201 chronic atrophic gastritis patients who visited the Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine and Dong'erhuan Branch between January 2022 and March 2023 were retrospectively analyzed, including 32 patients with HGIN (HGIN group) and 169 patients with moderate and severe chronic atrophic gastritis (non-HGIN group). The information of demographic characteristics, dietary habits, lifestyle factors, social and psychosocial factors, family history of tumors, medical history and comorbidities, long-term medication, endoscopic findings, histopathological examination results, as well as TCM syndrome types were collected. Potential HGIN risk factors were screened using LASSO regression, and the significant risk factors for establishing an HGIN risk prediction model were identified using logistic regression analysis. The final model was visually presented using a nomogram, and its diagnostic performance was evaluated through receiver operating characteristic curve analysis.
RESULTS:Spleen-stomach Qi deficiency was the most common TCM syndrome in both HGIN and non-HGIN groups. LASSO-logistic regression model analysis showed that heavy alcohol consumption (X1), syndrome of static blood in stomach collaterals (X2), low-grade intraepithelial neoplasia (X3), high-salt diet (X4), and age (X5) were independent risk factors related to the occurrence of HGIN, and the predictive model was ln［P/(1－P)］=2.159X1+2.230X2+1.664X3+2.070X4+0.122X5- 11.096. The model demonstrated good discriminative ability, calibration, and goodness-of-fit, with area under the curve values of 0.940 and 0.891 in the training and validation sets, respectively.
CONCLUSIONS:The TCM syndrome of static blood in stomach collaterals shows correlation with the transformation from chronic atrophic gastritis to HGIN. The HGIN prediction model based on TCM syndrome patterns developed in the study demonstrates potential value in clinical application.
