Research of tricuspid regurgitation associated with cardiac implantable electronic devices.
10.3724/zdxbyxb-2024-0396
- Author:
Danqing YU
1
;
Yan LIN
2
;
Qi CHEN
3
;
Xianbao LIU
4
;
Jian'an WANG
2
Author Information
1. Department of Cardiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, State Key Laboratory of Transvascular Implantation Devices, Zhejiang Provincial Key Laboratory of Cardiovascular Disease Diagnosis and Treatment, Hangzhou 310009, China. y222180237@zju.edu.cn.
2. Department of Cardiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, State Key Laboratory of Transvascular Implantation Devices, Zhejiang Provincial Key Laboratory of Cardiovascular Disease Diagnosis and Treatment, Hangzhou 310009, China.
3. Department of Cardiovascular Intervention, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
4. Department of Cardiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, State Key Laboratory of Transvascular Implantation Devices, Zhejiang Provincial Key Laboratory of Cardiovascular Disease Diagnosis and Treatment, Hangzhou 310009, China. liuxb@zju.edu.cn.
- Publication Type:English Abstract
- Keywords:
Cardiac implantable electronic devices;
Diagnosis;
Management;
Pathogenesis;
Prevention;
Review;
Tricuspid regurgitation
- MeSH:
Tricuspid Valve Insufficiency/diagnosis*;
Humans;
Defibrillators, Implantable/adverse effects*;
Pacemaker, Artificial/adverse effects*
- From:
Journal of Zhejiang University. Medical sciences
2025;54(2):219-229
- CountryChina
- Language:Chinese
-
Abstract:
Tricuspid regurgitation associated with cardiac implantable electronic devices (CIED) constitutes a significant subset of secondary tricuspid regurgitation, characterized by a multifactorial etiology involving pacing lead-mediated mechanical interference and CIED-related systemic factors. The pathogenesis of CIED-related tricuspid regurgitation encompasses direct mechanical trauma or functional disruption of the tricuspid valve apparatus by pacing leads, pacing mode-induced hemodynamic alterations, and clinical risk factors such as permanent atrial fibrillation, apical pacing, and high right ventricular pacing burden. The natural progression and clinical outcomes of CIED-related tricuspid regurgitation parallel those of tricuspid regurgitation stemming from other etiologies. Advanced imaging modalities, including echocardiography, cardiac computed tomography, and cardiac magnetic resonance imaging, enable precise diagnosis and longitudinal assessment of CIED-related tricuspid regurgitation. Management strategies emphasize multidisciplinary collaboration as well as integration of preventive approaches-such as refined lead implantation techniques and tailored pacing modalities-with therapeutic interventions ranging from pharmacotherapy to surgical valve repair or replacement. This article reviews the current understanding of CIED-related tricuspid regurgitation to provide a reference for clinical practice and research.
