Efficacy of the transcatheter tricuspid valve replacement for patients with severe tricuspid regurgitation: Lux-Valve versus Lux-Valve Plus.
10.3724/zdxbyxb-2024-0365
- Author:
Yandan SUN
1
,
2
;
Liang CAO
3
;
Wei BAI
3
;
Yuxi LI
3
;
Jian YANG
4
;
Guomeng JIANG
3
;
Yang LIU
4
;
Ping JIN
4
;
Liwen LIU
3
;
Xin MENG
2
,
5
Author Information
1. Department of Ultrasound Medicine, the First Affiliated Hospital of the Air Force Medical University (Xijing Hospital), Xi'an 710032, China. yandansun@
2. com.
3. Department of Ultrasound Medicine, the First Affiliated Hospital of the Air Force Medical University (Xijing Hospital), Xi'an 710032, China.
4. Department of Cardiovascular Surgery, the First Affiliated Hospital of the Air Force Medical University (Xijing Hospital), Xi'an 710032, China］.
5. Department of Ultrasound Medicine, the First Affiliated Hospital of the Air Force Medical University (Xijing Hospital), Xi'an 710032, China. mxfmmu@
- Publication Type:English Abstract
- Keywords:
Clinical efficacy;
Echocardiography;
Lux-Valve;
Lux-Valve Plus;
Transcatheter tricuspid valve replacement;
Tricuspid regurgitation
- MeSH:
Humans;
Tricuspid Valve Insufficiency/surgery*;
Male;
Female;
Heart Valve Prosthesis Implantation/methods*;
Middle Aged;
Aged;
Tricuspid Valve/surgery*;
Heart Valve Prosthesis;
Treatment Outcome;
Echocardiography;
Adult;
Cardiac Catheterization/methods*
- From:
Journal of Zhejiang University. Medical sciences
2025;54(2):213-218
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To compare the efficacy of transcatheter tricuspid valve replacement (TTVR) using Lux-Valve and Lux-Valve Plus in patients with severe tricuspid regurgitation.
METHODS:A total of 28 consecutive patients with severe tricuspid regurgitation who underwent TTVR with Lux-Valve (n=14) or Lux-Valve Plus (n=14) in the First Affiliated Hospital of the Air Force Medical University from August 2019 to November 2023 were enrolled. Transthoracic echocardiography was performed in all patients before and 6 months after the TTVR. The ultrasound indexes were compared before and 6 months after the TTVR in all patients and between Lux-Valve and Lux-Valve Plus groups.
RESULTS:Compared with the Lux-Valve group, the Lux-Valve Plus group showed significantly reduced intraoperative bleeding and shorter postoperative hospital stays (both P<0.05). Six months after the TTVR, none of the patients exhibited more than a mild tricuspid valve regurgitation, and none of the patients had moderate or above perivalvular leakage except for one patient in the Lux-Valve Plus group who had a separation of the clamping member from the anterior tricuspid leaflet. The incidence of perivalvular leakage was significantly lower in the Lux-Valve Plus group (14.29%, 2/14) than in the Lux-Valve group (64.29%, 9/14, P<0.05). At 6 months after operation, the right chamber volume and right ventricle middle transverse diameter were reduced (both P<0.05); the peak blood flow velocity across the tricuspid valve, peak pressure gradient across the tricuspid valve, mean blood flow velocity of tricuspid valve, mean pressure gradient across the tricuspid valve and velocity time integral were increased in both groups (all P<0.05).Compared with the Lux-Valve group, the Lux-Valve Plus group showed higher left ventricular ejection fraction at 6 months postoperatively (P<0.05), while the rest of the indicators were not statistically different (all P>0.05).
CONCLUSIONS:The efficacy of using Lux-Valve and Lux-Valve Plus for TTVR in patients with severe tricuspid regurgitation is comparable. Six months after the TTVR, the right side of the heart has undergone reverse remodeling.While Lux-Valve Plus offers greater minimally invasive benefits, valve selection should consider device-specific characteristics and differences in individual patients.
