Research progress on glycolipid metabolism of Sertoli cell in the development of spermatogenic cell.
10.3724/zdxbyxb-2024-0346
- Author:
Shuhao LI
1
;
Liang KONG
2
;
Jingyan LIANG
3
;
Tan MA
4
,
5
Author Information
1. Institute of Translational Medicine, Yangzhou University Medical College, Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou 225009, Jiangsu Province, China. 1979490910@qq.com.
2. Institute of Translational Medicine, Yangzhou University Medical College, Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou 225009, Jiangsu Province, China.
3. Institute of Translational Medicine, Yangzhou University Medical College, Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou 225009, Jiangsu Province, China. jyliang@yzu.edu.cn.
4. Institute of Translational Medicine, Yangzhou University Medical College, Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou 225009, Jiangsu Province, China. mtllyj@
5. com.
- Publication Type:English Abstract
- Keywords:
Glucose metabolism;
Lipid metabolism;
Mechanism;
Review;
Sertoli cell;
Spermatogenesis;
Spermatogenic cell
- MeSH:
Sertoli Cells/cytology*;
Male;
Glycolipids/metabolism*;
Spermatogenesis/physiology*;
Humans;
Lipid Metabolism;
Animals;
Fatty Acids/metabolism*;
Signal Transduction;
Glycolysis
- From:
Journal of Zhejiang University. Medical sciences
2025;54(2):257-265
- CountryChina
- Language:Chinese
-
Abstract:
Sertoli cells play an important role in the process of spermatogenesis, and the abnormalities in spermatogenesis are closely related to disruptions in glycolipid metabolism. The metabolic environment of Sertoli cells is hypoxic, with glycolysis and fatty acid β-oxidation being the primary metabolic pathways. In Sertoli cells, glycolysis produces lactate to provide energy for spermatogenic cells, while fatty acid β-oxidation generates ATP. Currently, the relationship between glycolipid metabolism in Sertoli cells and spermatogenic cell development, as well as the interplay between glucose and lipid metabolism remain unclear. Various hormones, including sex hormones, can affect glucose metabolism in Sertoli cells by endocrine regulation. The activation or inhibition of signaling pathways such as AMPK, mTOR, and Akt can alter the expression levels of glycolysis-related transporter genes and the synthesis of fatty acids, thereby affecting glycolipid metabolism in Sertoli cells. Some transcription factors such as PPARγ can regulate downstream fatty acid metabolism-related genes by directly binding to their response elements and promoting the oxidation of fatty acids in Sertoli cells. In this article we elaborate on the key factors influencing glycolipid metabolism in Sertoli cells and their interconnections, as well as their potential clinical implications, offering new insights for precisely targeted treatments of male infertility.
