Pathogenesis and treatment progression of myelodysplastic syndrome combined with Behçet's syndrome.
10.3724/zdxbyxb-2024-0150
- Author:
Hui FU
1
,
2
;
Jian YU
3
Author Information
1. Department of Hematology and Oncology, Taizhou Hospital of Zhejiang Province, Taizhou 317000, Zhejiang Province, China. fhdoct@
2. com.
3. Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. zjuyujian@zju.edu.cn.
- Publication Type:English Abstract
- Keywords:
Behçet’s syndrome;
Heredity;
Immunology;
Myelodysplastic syndrome;
Review;
Treatment
- MeSH:
Humans;
Behcet Syndrome/pathology*;
Myelodysplastic Syndromes/pathology*;
Disease Progression
- From:
Journal of Zhejiang University. Medical sciences
2025;54(1):131-139
- CountryChina
- Language:Chinese
-
Abstract:
Myelodysplastic syndromes (MDS) are clonal hematopoietic neoplasms characterized by chronic cytopenias and abnormal cell morphology, with a propensity of progressing to bone marrow failure or acute myeloid leukemia. Behçet's syndrome is a systemic vasculitis characterized by recurrent oral ulcers, skin lesions, and ocular inflammation. In recent years, an increasing number of clinical cases with coexistence of MDS and Behçet's syndrome have been reported, suggesting a potential pathological relationship between these conditions. Abnormal immune cell activation, dysregulated cytokine secretion, and cytogenetic alterations are thought to play critical roles in the pathogenesis of MDS combined with Behçet's syndrome. Currently, treatment strategies for MDS combined with Behçet's syndrome are primarily individualized and include immunosuppressive therapy, cytotoxic drug therapy, targeted therapy, and hematopoietic stem cell transplantation. However, due to the limited number of case reports and insufficient research on the underlying mechanisms, selecting appropriate treatment options remains challenging. This article reviews the pathogenesis and interrelationships of MDS combined with Behçet's syndrome and summarizes recent advancements in treatment strategies, providing a reference for clinical management and further researches on related mechanisms.
