Mechanism and significance of cell senescence induced by viral infection.
10.3724/zdxbyxb-2024-0213
- Author:
Yunchuang CHANG
1
,
2
;
Xinna WU
3
;
Lingli DENG
4
;
Sanying WANG
2
,
5
;
Genxiang MAO
2
,
6
Author Information
1. College of Biological and Food Engineering, Hubei Minzu University, Enshi 445000, Hubei Province, China. cyc147927@
2. com.
3. Zhejiang University School of Medicine, Hangzhou 310058, China.
4. College of Biological and Food Engineering, Hubei Minzu University, Enshi 445000, Hubei Province, China.
5. Zhejiang Provincial Geriatrics Institute, Zhejiang Key Laboratory of Geriatrics, Zhejiang Hospital, Hangzhou 310030, China. sanyingwang309@
6. College of Biological and Food Engineering, Hubei Minzu University, Enshi 445000, Hubei Province, China. maogenxiang@
- Publication Type:English Abstract
- Keywords:
Cell senescence;
DNA damage response;
Review;
Viral infection;
cGAS-STING
- MeSH:
Humans;
Cellular Senescence/physiology*;
Virus Diseases/physiopathology*;
Signal Transduction;
Nucleotidyltransferases/metabolism*;
DNA Damage;
Virus Replication;
COVID-19;
Membrane Proteins/metabolism*;
SARS-CoV-2
- From:
Journal of Zhejiang University. Medical sciences
2025;54(1):70-80
- CountryChina
- Language:Chinese
-
Abstract:
Virus-induced senescence (VIS) is a significant biological phenomenon, which is associated with declining immune function, accelerating aging process and causing aging-related diseases. A variety of common viruses, including RNA viruses (such as SARS-CoV-2), DNA viruses (such as herpesviruses and hepatitis B virus), and prions can cause VIS in host cells. The primary mechanisms include abnormal activation of the cGAS-STING signaling pathway, DNA damage response, and potential correlations with the integrated stress response due to intracellular phase separation. Viral infection and cellular senescence influence each other: cellular senescence serves as a defense to restrict viral replication and transmission, while some viruses exploit cellular senescence to enhance their infectivity and replication. Understanding the mechanisms of VIS is conducive to the development of therapeutic strategies for viral infections and promotion of healthy aging. However, there is lack of research on therapeutic targets and drug development in this field so far. Although senolytics may be effective for anti-senescent cells therapy, their efficacy for VIS needs evidence from further clinical trials. This article reviews the research progress on the connection between viral infection and cellular senescence, to provide insights for the prevention and treatment of aging related diseases.
