Advances in inflammaging in liver disease.
10.3724/zdxbyxb-2024-0249
- Author:
Yanping XU
1
;
Luyi CHEN
2
;
Weili LIU
2
;
Liying CHEN
3
Author Information
1. Department of General Practice, Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China. yanpingxu@zju.edu.cn.
2. Department of General Practice, Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
3. Department of General Practice, Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China. 3197020@zju.edu.cn.
- Publication Type:English Abstract
- Keywords:
Inflammaging;
Intervention;
Liver diseases;
Mechanism;
Review
- MeSH:
Humans;
Liver Diseases/pathology*;
Inflammation;
Oxidative Stress;
Non-alcoholic Fatty Liver Disease;
Liver Neoplasms;
Gastrointestinal Microbiome
- From:
Journal of Zhejiang University. Medical sciences
2025;54(1):90-98
- CountryChina
- Language:Chinese
-
Abstract:
Inflammaging is a process of cellular dysfunction associated with chronic inflammation, which plays a significant role in the onset and progression of liver diseases. Research on its mechanisms has become a hotspot. In viral hepatitis, inflammaging primarily involve oxidative stress, cell apoptosis and necrosis, as well as gut microbiota dysbiosis. In non-alcoholic fatty liver disease, inflammaging is more complex, involving insulin resistance, fat deposition, lipid metabolism disorders, gut microbiota dysbiosis, and abnormalities in NAD+ metabolism. In liver tumors, inflammaging is characterized by weakening of tumor suppressive mechanisms, remodeling of the liver microenvironment, metabolic reprogramming, and enhanced immune evasion. Therapeutic strategies targeting inflammaging have been developing recently, and antioxidant therapy, metabolic disorder improvement, and immunotherapy are emerging as important interventions for liver diseases. This review focuses on the mechanisms of inflammaging in liver diseases, aiming to provide novel insights for the prevention and treatment of liver diseases.
