Ferroptosis and liver diseases.
10.3724/zdxbyxb-2024-0566
- Author:
Xin LI
1
,
2
;
Liang TAO
3
;
Meijuan ZHONG
3
;
Qian WU
4
;
Junjia MIN
4
;
Fudi WANG
5
Author Information
1. School of Pharmacy, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China. lx19834146185@
2. com.
3. College of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China.
4. Zhejiang University School of Medicine, Hangzhou 310058, China.
5. College of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China. fwang@zju.edu.cn.
- Publication Type:English Abstract
- Keywords:
Ferroptosis;
Ferroptotic signaling pathway;
Iron metabolism;
Liver disease;
Review
- MeSH:
Humans;
Liver Diseases/etiology*;
Ferroptosis/physiology*;
Liver Neoplasms/pathology*;
Carcinoma, Hepatocellular/pathology*;
Liver Cirrhosis/etiology*;
Liver/pathology*;
Hepatitis, Autoimmune/metabolism*;
Liver Diseases, Alcoholic/metabolism*
- From:
Journal of Zhejiang University. Medical sciences
2024;53(6):747-755
- CountryChina
- Language:Chinese
-
Abstract:
As the central organ of metabolism, the liver plays a pivotal role in the regulation of the synthesis and metabolism of various nutrients within the body. Ferroptosis, as a newly discovered type of programmed cell death caused by the accumulation of iron-dependent lipid peroxides, is involved in the physiological and pathological processes of a variety of acute and chronic liver diseases. Ferroptosis can accelerate the pathogenetic process of acute liver injury, metabolic associated fatty liver disease, alcoholic liver disease, viral hepatitis, and autoimmune hepatitis; while it can slower disease progression in advanced liver fibrosis and hepatocellular carcinoma. This suggests that targeted regulation of ferroptosis may impact the occurrence and development of various liver diseases. This article reviews the latest research progress of ferroptosis in various liver diseases, including acute liver injury, metabolic associated fatty liver disease, alcoholic liver disease, viral hepatitis, autoimmune hepatitis, liver fibrosis and hepatocellular carcinoma. It aims to provide insights for the prevention and treatment of acute and chronic liver diseases through targeting ferroptosis.
