Research progress on the role of ferroptosis in aortic dissection.
10.3724/zdxbyxb-2024-0186
- Author:
Xiang HONG
1
;
Yuchong ZHANG
2
;
Weiguo FU
3
;
Lixin WANG
4
Author Information
1. Department of Vascular Surgery, Zhongshan Hospital, Fudan University (Xiamen Branch), Xiamen 361015, Fujian Province, China. kelvin_920@qq.com.
2. Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Vascular Surgery Institute of Fudan University, National Clinical Research Center for Interventional Medicine, Shanghai 200032, China］.
3. Department of Vascular Surgery, Zhongshan Hospital, Fudan University (Xiamen Branch), Xiamen 361015, Fujian Province, China.
4. Department of Vascular Surgery, Zhongshan Hospital, Fudan University (Xiamen Branch), Xiamen 361015, Fujian Province, China. wang.lixin@zs-hospital.sh.cn.
- Publication Type:English Abstract
- Keywords:
Aortic dissection;
Ferroptosis;
Pathogenesis;
Review
- MeSH:
Ferroptosis;
Humans;
Aortic Dissection/etiology*;
Lipid Peroxidation;
Iron/metabolism*;
Oxidative Stress;
Risk Factors;
Animals
- From:
Journal of Zhejiang University. Medical sciences
2024;53(6):726-734
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies have shown that iron metabolism dysregulation and lipid peroxidation-induced ferroptosis, triggered by oxidative stress, play a key role in the development of aortic dissection. Dysregulated iron metabolism leads to excessive production of hydroxyl radicals due to abnormal iron levels and heme metabolism, while lipid peroxidation is linked to system Xc－ dysfunction and accumulation of phospholipid hydroperoxides. These factors synergistically disrupt aortic homeostasis and drive ferroptosis in vascular cells, including endothelial and smooth muscle cells. Furthermore, disruptions in ferroptosis-related genes, along with risk factors such as smoking, epigenetic modifications such as protein methylation, and abnormalities in immune cells, particularly T cells, are closely linked to aortic dissection. Several small molecules and nanomaterials have shown potential in inhibiting ferroptosis in this context. This review elucidates the roles of ferroptosis in aortic dissection and proposes strategies for its targeted prevention and treatment.
