Research progress on metal pollutants inducing neurotoxicity through ferroptosis.
10.3724/zdxbyxb-2024-0127
- Author:
Ziyu QIN
1
,
2
;
Yuqing CHEN
3
;
Xinyuan ZHAO
3
;
Shali YU
4
Author Information
1. Department of Occupational Medicine and Environmental Health, School of Public Health, Nantong University, Nantong Municipal Key Laboratory of Environmental Toxicology, Nantong 226019, Jiangsu Province, China. qinziyu19855360753@
2. com.
3. Department of Occupational Medicine and Environmental Health, School of Public Health, Nantong University, Nantong Municipal Key Laboratory of Environmental Toxicology, Nantong 226019, Jiangsu Province, China.
4. Department of Occupational Medicine and Environmental Health, School of Public Health, Nantong University, Nantong Municipal Key Laboratory of Environmental Toxicology, Nantong 226019, Jiangsu Province, China. 7693539@ntu.edu.cn.
- Publication Type:English Abstract
- Keywords:
Ferroptosis;
Metal pollutant;
Molecular mechanism;
Neurotoxicity;
Review
- MeSH:
Ferroptosis/drug effects*;
Humans;
Iron/metabolism*;
Oxidative Stress/drug effects*;
Neurotoxicity Syndromes/metabolism*;
Cadmium/adverse effects*;
Animals;
Lipid Peroxidation/drug effects*;
Metals/metabolism*;
Lead/adverse effects*;
Environmental Pollutants/toxicity*;
Manganese/adverse effects*;
Nickel/adverse effects*;
Mitochondria/drug effects*;
Signal Transduction/drug effects*
- From:
Journal of Zhejiang University. Medical sciences
2024;53(6):699-707
- CountryChina
- Language:Chinese
-
Abstract:
It has been confirmed that exposure to various metal pollutants can induce neurotoxicity, which is closely associated with the occurrence and development of neurological disorders. Ferroptosis is a form of cell death in response to metal pollutant exposure and it is closely related to oxidative stress, iron metabolism and lipid peroxidation. Recent studies have revealed that ferroptosis plays a significant role in the neurotoxicity induced by metals such as lead, cadmium, manganese, nickel, and antimony. Lead exposure triggers ferroptosis through oxidative stress, iron metabolism disorder and inflammation. Cadmium can induce ferroptosis through iron metabolism, oxidative stress and ferroptosis related signaling pathways. Manganese can promote ferroptosis through mitochondrial dysfunction, iron metabolism disorder and oxidative stress. Nickel can promote ferroptosis by influencing mitochondrial function, disrupting iron homeostasis and facilitating lipid peroxidation in the central nervous system. Antimony exposure can induce glutathione depletion by activating iron autophagy, resulting in excessive intracellular iron deposition and ultimately causing ferroptosis. This article reviews the effects of metal pollutants on ferroptosis-related indicators and discusses the specific mechanisms by which each metal triggers ferroptosis. It provides a reference for identifying targets for preventing neurotoxicity and for developing treatment strategies for neurological disorders.
