The microbiota-gut-brain axis in childhood attention-deficit/hyperactivity disorder: mechanisms and therapeutic advances.
10.7499/j.issn.1008-8830.2503118
- Author:
Ying-Lun YUAN
1
;
Yong-Mei LAN
1
;
Lin-Mei GUO
Author Information
1. Department of Pediatrics, 940th Hospital of Joint Service Support Force of the People's Liberation Army, Lanzhou 730050, China.
- Publication Type:English Abstract
- Keywords:
Attention-deficit/hyperactivity disorder;
Child;
Gut microbiota;
Microbiota-gut-brain axis;
Microbiota-targeted therapy
- MeSH:
Humans;
Attention Deficit Disorder with Hyperactivity/microbiology*;
Gastrointestinal Microbiome/physiology*;
Child;
Brain/physiology*;
Dysbiosis
- From:
Chinese Journal of Contemporary Pediatrics
2025;27(11):1426-1432
- CountryChina
- Language:Chinese
-
Abstract:
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children. Growing evidence links ADHD to gut microbiota dysbiosis, positioning the microbiota-gut-brain axis as a new focus of childhood ADHD research. This review systematically elucidates the association between gut dysbiosis and childhood ADHD and analyzes key mechanisms by which the microbiota-gut-brain axis regulates bidirectional gut-brain communication through multiple pathways. It highlights recent findings on microbiota-targeted strategies to improve ADHD symptoms and discusses therapeutic prospects, with the aim of exploring new avenues for early intervention and treatment in children with ADHD.
