Risk factors for white matter damage in preterm infants with necrotizing enterocolitis.
10.7499/j.issn.1008-8830.2507132
- Author:
Xin XU
1
;
Si-Rui WANG
1
;
Peng ZHANG
;
Guo-Qiang CHENG
Author Information
1. Department of Neonatology, Children's Hospital of Fudan University, Shanghai 201102, China.
- Publication Type:Journal Article
- Keywords:
Magnetic resonance imaging;
Necrotizing enterocolitis;
Preterm infant;
Risk factor;
White matter damage
- MeSH:
Humans;
Enterocolitis, Necrotizing/complications*;
Infant, Newborn;
Male;
Female;
Risk Factors;
Retrospective Studies;
Infant, Premature;
White Matter/diagnostic imaging*;
Logistic Models;
Magnetic Resonance Imaging
- From:
Chinese Journal of Contemporary Pediatrics
2025;27(11):1333-1338
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To investigate the risk factors for white matter damage (WMD) in preterm infants with necrotizing enterocolitis (NEC).
METHODS:A retrospective analysis was conducted on the clinical data of 249 preterm infants with NEC admitted to Children's Hospital of Fudan University between January 2021 and December 2023. Based on brain magnetic resonance imaging (MRI) white matter scores, the infants were categorized into a WMD group (≥7 points) and a non-injury group (<7 points). A multivariable logistic regression analysis was performed to identify risk factors for WMD.
RESULTS:Compared with the non-injury group, the WMD group had significantly higher rates of Gram-negative bacterial infection (43.1% vs 28.2%), surgical treatment (47.2% vs 23.2%), and moderate-to-severe abnormalities on video electroencephalography (VEEG) (51.4% vs 11.9%) (all P<0.05). The multivariable logistic regression analysis showed that surgical treatment (OR=1.822, 95%CI: 1.199-2.777), longer hospital stay (OR=1.041, 95%CI: 1.004-1.080), and moderate-to-severe VEEG abnormalities (OR=7.045, 95%CI: 3.349-14.855) were independent risk factors for WMD (all P<0.05).
CONCLUSIONS:Surgical treatment, prolonged hospitalization, and moderate-to-severe VEEG abnormalities are independent risk factors for WMD in preterm infants with NEC, providing a basis for early clinical identification and intervention to improve neurological outcomes.
