Expert consensus on the diagnosis, treatment, and prevention of neonatal dengue, chikungunya, and Zika virus infections (2025).
10.7499/j.issn.1008-8830.2508104
- Collective Name:Perinatal Group, Pediatric Branch of the Chinese Medical Doctor Association; Editorial Board, Chinese Journal of Contemporary Pediatrics
- Publication Type:Consensus Development Conference
- Keywords:
Chikungunya;
Consensus;
Dengue;
Mosquito-borne virus;
Neonate;
Zika virus disease
- MeSH:
Humans;
Zika Virus Infection/therapy*;
Infant, Newborn;
Chikungunya Fever/therapy*;
Dengue/prevention & control*;
Female;
Pregnancy;
Consensus
- From:
Chinese Journal of Contemporary Pediatrics
2025;27(10):1155-1166
- CountryChina
- Language:Chinese
-
Abstract:
Mosquito-borne viruses, including dengue virus (DENV), chikungunya virus (CHIKV), and Zika virus (ZIKV), pose major threats to public health in tropical and subtropical regions worldwide. Neonates are particularly vulnerable, and the associated disease burden has drawn increasing attention. Routes of neonatal infection include vertical mother-to-child transmission (transplacental and peripartum) and postnatal mosquito bites. Clinical manifestations are often nonspecific; a proportion of cases may progress to central nervous system infection, hemorrhagic disease, or long-term neurodevelopmental impairment, with serious consequences for survival and quality of life. Although China has issued prevention and control guidelines for adults and pregnant women, systematic clinical guidance tailored to neonates remains lacking. In response, the Perinatal Group of the Pediatric Branch of the Chinese Medical Doctor Association convened a multidisciplinary panel to develop this expert consensus, integrating the latest international evidence with China's practical prevention and control experience. The consensus addresses epidemiology; the effects of maternal infection on fetuses and neonates; clinical manifestations; diagnosis and differential diagnosis; early warning indicators of severe disease; therapeutic strategies and supportive care; and prevention and maternal-infant management. It aims to provide evidence-based, standardized, and practical guidance for frontline clinicians managing neonatal mosquito-borne viral infections.
