Granulomatous primary central nervous system vasculitis in a child.
10.7499/j.issn.1008-8830.2503053
- Author:
Ya-Nan ZHANG
1
;
Chang-Hong DING
1
;
Shu-Hong REN
1
;
Wei-Hua ZHANG
;
Fang LIU
;
Nan ZHANG
;
Yu-Juan ZHANG
1
Author Information
1. Department of Neurology, Baoding Hospital Affiliated to Beijing Children's Hospital, Capital Medical University, Baoding, Hebei 071000, China.
- Publication Type:English Abstract
- Keywords:
Brain biopsy;
Child;
Granuloma;
Primary central nervous system vasculitis
- MeSH:
Humans;
Male;
Vasculitis, Central Nervous System/diagnosis*;
Adolescent;
Magnetic Resonance Imaging;
Granuloma/diagnosis*
- From:
Chinese Journal of Contemporary Pediatrics
2025;27(9):1140-1142
- CountryChina
- Language:Chinese
-
Abstract:
A 14-year-old boy was admitted to the hospital due to a single episode of afebrile seizure and four hours of impaired consciousness. Three months prior to admission, he had a history of bilateral uveitis. Cerebrospinal fluid analysis revealed a mild elevation in white blood cell count. Cranial magnetic resonance imaging and contrast-enhanced scans showed multiple abnormal signals in both cerebral hemispheres, with punctate and nodular enhancement. Susceptibility-weighted imaging revealed multiple punctate hemorrhages within lesions in the bilateral frontal and left parietal lobes, suggestive of vasculitis. Brain biopsy demonstrated inflammatory granulomatous lesions. No secondary causes were identified, and the final diagnosis was granulomatous primary central nervous system vasculitis. The patient's condition improved after treatment with methylprednisolone sodium succinate and mycophenolate mofetil. This report describes a rare case of granulomatous central nervous system vasculitis in a child and provides valuable insights for the diagnosis and treatment of this disease.
