Causal relationship between Helicobacter pylori infection and childhood immune thrombocytopenia and influencing factors for prognosis.
10.7499/j.issn.1008-8830.2412180
- Author:
Xiao-Yang ZHOU
1
;
Mei YAN
1
;
Ying-Bin YUE
1
;
Hailigulli NURIDDIN
1
;
Xue-Mei WANG
1
;
Yong-Feng CHENG
1
;
Chun-Can WU
1
;
Yu LIU
1
Author Information
1. Department of Internal Pediatrics, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
- Publication Type:Journal Article
- Keywords:
Child;
Clinical study;
Helicobacter pylori;
Immune thrombocytopenia;
Mendelian randomization
- MeSH:
Humans;
Helicobacter Infections/complications*;
Purpura, Thrombocytopenic, Idiopathic/etiology*;
Child;
Male;
Female;
Helicobacter pylori;
Prognosis;
Child, Preschool;
Logistic Models;
Retrospective Studies;
Risk Factors;
Polymorphism, Single Nucleotide;
Adolescent;
Infant
- From:
Chinese Journal of Contemporary Pediatrics
2025;27(9):1105-1112
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To investigate the causal relationship between Helicobacter pylori (Hp) infection and immune thrombocytopenia (ITP) using Mendelian randomization (MR), as well as the association between Hp infection and chronic ITP (cITP) through a clinical study.
METHODS:The datasets from genome-wide association studies were used to select the single nucleotide polymorphism loci significantly associated with Hp infection as genetic instrumental variables. The MR analysis model was used to investigate the causal relationship between ITP and Hp infection. A retrospective analysis was conducted on the medical data of 316 children with newly diagnosed ITP at the First Affiliated Hospital of Xinjiang Medical University from January 2020 to December 2023. The children were followed up for 1 year, and a multivariate logistic regression analysis was used to investigate the risk factors for cITP.
RESULTS:The inverse variance weighted analysis revealed that Hp infection was significantly associated with an increased risk of ITP (OR=1.280, 95%CI: 1.098-1.492, P=0.002). There was no heterogeneity or pleiotropy in this MR study (P>0.05), and the model was stable. The "leave-one-out" sensitivity analysis verified the reliability of the results. The multivariate logistic regression analysis demonstrated that Hp infection was an independent risk factor for progression to cITP (OR=7.916, 95%CI: 3.327-18.832, P<0.001).
CONCLUSIONS:Hp infection is a risk factor for the onset of ITP and is an independent risk factor for cITP in children.
