Research progress on the cGAS-STING signaling pathway in immune-mediated inflammatory diseases in children.
10.7499/j.issn.1008-8830.2412098
- Author:
Xin-Yue WEI
1
;
Xiao-Juan GONG
1
;
Hong JI
1
Author Information
1. Department of Pediatrics, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116000, China.
- Publication Type:English Abstract
- Keywords:
Autoimmune disease;
Child;
Cyclic GMP-AMP synthase;
Signaling pathway;
Stimulator of interferon gene;
autoinflammatory diseases
- MeSH:
Humans;
Nucleotidyltransferases/physiology*;
Membrane Proteins/physiology*;
Signal Transduction/physiology*;
Child;
Autoimmune Diseases/immunology*;
Inflammation/etiology*
- From:
Chinese Journal of Contemporary Pediatrics
2025;27(7):881-887
- CountryChina
- Language:Chinese
-
Abstract:
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon gene (STING) signaling pathway is a crucial component of the immune system. It detects abnormal cytosolic double-stranded DNA and promotes the expression of type I interferons and other inflammatory factors, thereby protecting the body from pathogenic infections. In children, an immature immune system or genetic mutations can lead to immune dysregulation, increasing the risk of autoimmune diseases (AID) and autoinflammatory diseases. Recent studies have shown that aberrant activation of the cGAS-STING signaling pathway is associated with the development of AID and autoinflammatory diseases in children. This review summarizes the research progress on the cGAS-STING signaling pathway in childhood AID and autoinflammatory diseases, aiming to provide new directions for clinical diagnosis and treatment.
