Investigating the correlation between white matter injury and cerebral perfusion in preterm infants using arterial spin labeling.
10.7499/j.issn.1008-8830.2501047
- Author:
Xiang-Bo KONG
1
;
Fan-Yue QIN
1
;
Wen-Li DUAN
1
;
Lin LU
;
Xiao-Chan GUO
1
;
Yan-Ran XUE
1
;
Yin-Gang HONG
1
;
Fa-Lin XU
1
Author Information
1. Department of Neonatology, Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
- Publication Type:Journal Article
- Keywords:
Arterial spin labeling;
Cerebral perfusion;
Preterm infant;
Region of interest;
White matter injury
- MeSH:
Humans;
White Matter/blood supply*;
Infant, Newborn;
Spin Labels;
Infant, Premature;
Female;
Male;
Cerebrovascular Circulation;
Magnetic Resonance Imaging
- From:
Chinese Journal of Contemporary Pediatrics
2025;27(6):661-667
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To explore the relationship between white matter injury (WMI) and cerebral perfusion in preterm infants using arterial spin labeling (ASL).
METHODS:A total of 293 preterm infants (gestational age <34 weeks) hospitalized at the Third Affiliated Hospital of Zhengzhou University between June 2022 and June 2024 were included. After achieving clinical stability, the infants underwent brain magnetic resonance imaging (MRI) and ASL. Based on MRI findings, infants were classified into WMI (n=66) and non-WMI (n=227) groups. Cerebral perfusion parameters were compared between groups, and the association between WMI and perfusion alterations was evaluated.
RESULTS:The WMI group showed a higher incidence of mild intraventricular hemorrhage (IVH) than the non-WMI group (P<0.05). Significantly lower cerebral perfusion was observed in the WMI group across bilateral frontal, temporal, parietal, and occipital lobes, as well as the basal ganglia and thalamus (P<0.05). After adjusting for gestational age, corrected gestational age at ASL scan, and mild IVH, WMI remained significantly associated with reduced regional perfusion (P<0.05).
CONCLUSIONS:WMI in preterm infants correlates with localized cerebral hypoperfusion. ASL-detected perfusion abnormalities may provide novel insights into WMI pathogenesis.
