Advances in research on gender differences in autism spectrum disorders.
10.7499/j.issn.1008-8830.2411142
- Author:
Tong-Tong JIANG
;
Xiu-Qiong LI
;
Ting-Ting ZHAO
;
Hong-Yu LI
1
;
Qiang TANG
1
Author Information
1. Department of Rehabilitation, Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150001, China.
- Publication Type:English Abstract
- Keywords:
Autism spectrum disorder;
DNA methylation;
Epigenetics;
Female protective effect;
Gender difference;
Genetics;
Hormone level
- MeSH:
Humans;
Autism Spectrum Disorder/genetics*;
Female;
Male;
DNA Methylation;
Sex Factors;
Sex Characteristics
- From:
Chinese Journal of Contemporary Pediatrics
2025;27(4):480-486
- CountryChina
- Language:Chinese
-
Abstract:
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social impairments, repetitive behaviors, and restricted interests. Studies have shown that it is more prevalent in males than females. Although this issue has attracted academic attention since the 20th century, the specific mechanisms underlying the gender differences in ASD remain unclear. This paper reviews the impact of gender differences in ASD, focusing on the female protective effect, DNA methylation, hormone levels, and clinical manifestations. It also discusses corresponding treatment options, particularly suggesting improvements in the diagnostic process, which is often overlooked, in order to provide valuable references for the clinical diagnosis and treatment of ASD.
