Association between insulin resistance and uterine volume in girls with idiopathic central precocious puberty.
10.7499/j.issn.1008-8830.2411003
- Author:
Hong-Ru ZHANG
1
;
Ya XIAO
1
;
Shu-Qin JIANG
1
;
Jun SUN
1
;
Wen-Hui SHI
1
;
Jin-Bo LI
1
;
Ying YANG
1
;
Wei WANG
1
Author Information
1. Department of Pediatrics, Third Affiliated Hospital of Zhengzhou University/Henan Maternal and Child Health Hospital, Zhengzhou 450052, China.
- Publication Type:Journal Article
- Keywords:
Child;
Hypothalamic-pituitary- gonadal axis;
Idiopathic central precocious puberty;
Insulin resistance;
Uterine volume
- MeSH:
Humans;
Female;
Insulin Resistance;
Puberty, Precocious/metabolism*;
Uterus/pathology*;
Child;
Retrospective Studies;
Organ Size;
Linear Models
- From:
Chinese Journal of Contemporary Pediatrics
2025;27(4):404-409
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To investigate the association between insulin resistance and uterine volume in girls with idiopathic central precocious puberty (ICPP).
METHODS:A retrospective study was conducted involving 61 girls diagnosed with ICPP who visited the pediatric growth and development clinic of the Third Affiliated Hospital of Zhengzhou University between January 2022 and September 2024, designated as the ICPP group, and 61 normally developing girls as the control group. The differences in insulin resistance index (homeostasis model assessment of insulin resistance, HOMA-IR), uterine volume, and other indicators between the two groups were compared, and the relationship between insulin resistance and uterine volume in these girls was analyzed.
RESULTS:The uterine volume and HOMA-IR level in the ICPP group were significantly higher than those in the control group (P<0.05). Correlation analysis revealed that there was a positive correlation between HOMA-IR level and uterine volume in the ICPP group (rs=0.643, P<0.001). Multiple linear regression analysis indicated that as HOMA-IR increased,uterine volume in the girls tended to increase (P<0.05).
CONCLUSIONS:There is an association between insulin resistance and uterine volume in girls with ICPP, and as HOMA-IR increases, uterine volume in the girls also increases.
