Monitoring and interventions of growth disorders and endocrine function in children with transfusion-dependent thalassemia.
10.7499/j.issn.1008-8830.2501080
- Author:
Xin FAN
1
;
Yi-Yun HUANG
1
Author Information
1. Department of Pediatrics, Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, China.
- Publication Type:English Abstract
- Keywords:
Endocrine dysfunction;
Growth and development;
Iron overload;
Recombinant human growth hormone;
Thalassemia
- MeSH:
Humans;
Thalassemia/physiopathology*;
Child;
Growth Disorders/diagnosis*;
Blood Transfusion;
Endocrine System Diseases/therapy*
- From:
Chinese Journal of Contemporary Pediatrics
2025;27(4):389-394
- CountryChina
- Language:Chinese
-
Abstract:
Transfusion-dependent thalassemia (TDT) is a severe genetic chronic hemolytic disease, and growth retardation is a common clinical feature in patients with TDT. Due to the need for regular blood transfusions, these patients often experience iron overload, which leads to various endocrine dysfunctions, including abnormalities in the growth hormone/insulin-like growth factor axis, hypothyroidism, hypoparathyroidism, hypogonadism, adrenal insufficiency, and decreased bone density. This paper reviews the clinical monitoring and intervention measures for growth disorders and related endocrine functions in patients with TDT, providing references for clinicians.
