Clinical analysis of 6 cases of diffuse panbronchiolitis in children.
10.7499/j.issn.1008-8830.2409125
- Author:
Li-Xin DENG
1
;
De-Hui CHEN
;
Yu-Neng LIN
;
Shang-Zhi WU
;
Jia-Xing XU
;
Zhan-Hang HUANG
;
Ying-Ying GU
;
Jun-Xiang FENG
Author Information
1. Department of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
- Publication Type:Journal Article
- Keywords:
Child;
Diagnosis;
Diffuse panbronchiolitis;
Non-tuberculous Mycobacteria
- MeSH:
Humans;
Male;
Female;
Bronchiolitis/drug therapy*;
Retrospective Studies;
Child;
Haemophilus Infections/diagnosis*
- From:
Chinese Journal of Contemporary Pediatrics
2025;27(3):334-339
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To analyze the clinical characteristics of diffuse panbronchiolitis (DPB) in children and to enhance the clinical diagnosis and treatment of this disease.
METHODS:A retrospective analysis was conducted on the clinical data of 6 children diagnosed with DPB who were hospitalized at The First Affiliated Hospital of Guangzhou Medical University from January 2011 to December 2019.
RESULTS:Among the 6 patients, there were 2 males and 4 females; the age at diagnosis ranged from 7 to 12 years. All patients presented with cough, sputum production, and exertional dyspnea, and all had a history of sinusitis. Two cases showed positive serum cold agglutinin tests, and 5 cases exhibited pathological changes consistent with chronic bronchiolitis. High-resolution chest CT in all patients revealed centrilobular nodules diffusely distributed throughout both lungs with a tree-in-bud appearance. Five patients received low-dose azithromycin maintenance therapy, but 3 showed inadequate treatment response. After empirical anti-tuberculosis treatment, non-tuberculous Mycobacteria were found in the bronchoalveolar lavage fluid. Follow-up over 2 years showed 1 case cured, 3 cases significantly improved, and 2 cases partially improved.
CONCLUSIONS:The clinical presentation of DPB is non-specific and can easily lead to misdiagnosis. In cases where DPB is clinically diagnosed but does not show improvement with low-dose azithromycin treatment, special infections should be considered.
