Clinical characteristics and risk factors of pyogenic liver abscess complicated by sepsis in children.
10.7499/j.issn.1008-8830.2410025
- Author:
Xue-Li WANG
1
;
Quan-Bo LIU
1
Author Information
1. Department of Infection, Children's Hospital Affiliated to Chongqing Medical University/National Clinical Research Center for Child Health and Disorders/Ministry of Education Key Laboratory of Child Development and Disorders/Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing 400014, China.
- Publication Type:Journal Article
- Keywords:
Child;
Clinical characteristic;
Pyogenic liver abscess;
Risk factor;
Sepsis
- MeSH:
Humans;
Liver Abscess, Pyogenic/blood*;
Male;
Female;
Risk Factors;
Retrospective Studies;
Sepsis/etiology*;
Child, Preschool;
Infant;
Child;
Leukocyte Count;
Logistic Models;
Adolescent;
Serum Albumin/analysis*
- From:
Chinese Journal of Contemporary Pediatrics
2025;27(3):328-333
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To study the clinical characteristics and risk factors of pyogenic liver abscess complicated by sepsis in children.
METHODS:A retrospective analysis was conducted on the clinical data of 120 children with pyogenic liver abscess admitted from May 2004 to January 2024. According to the presence of sepsis, the children were divided into a sepsis group (82 cases) and a non-sepsis group (38 cases). The clinical characteristics of the two groups were compared, and risk factors associated with the occurrence of sepsis were identified.
RESULTS:Among the 120 children with pyogenic liver abscess, 68.3% (82/120) had sepsis. Multivariate logistic regression analysis showed that fever, elevated white blood cell count, and decreased albumin level were closely associated with the occurrence of sepsis (P<0.05). Receiver operating characteristic curve analysis indicated that white blood cell count and albumin levels had significant predictive value for sepsis (P<0.05), and the combination of white blood cell count and albumin level showed higher predictive value for sepsis than the albumin level alone (P<0.05).
CONCLUSIONS:The clinical manifestations of children with pyogenic liver abscess complicated by sepsis are non-specific. Fever, elevated white blood cell count, and decreased albumin level are risk factors for sepsis in children with pyogenic liver abscess. Clinically, for children with unexplained fever and imaging suggestive of liver abscess, pyogenic liver abscess should be considered. If laboratory tests show elevated white blood cell count and decreased albumin level simultaneously, there should be a high level of suspicion for the development of sepsis.
