Research advances in maturity-onset diabetes of the young.
10.7499/j.issn.1008-8830.2408070
- Author:
Hui-Yun GENG
1
;
Zhi-Hua WANG
Author Information
1. Department of Endocrine, Genetics and Metabolism, Children's Hospital Affiliated to Xi'an Jiaotong University, Xi'an 710003, China.
- Publication Type:English Abstract
- Keywords:
Clinical manifestation;
Gene mutation;
Maturity-onset diabetes of the young;
Treatment
- MeSH:
Humans;
Diabetes Mellitus, Type 2/genetics*
- From:
Chinese Journal of Contemporary Pediatrics
2025;27(1):121-126
- CountryChina
- Language:Chinese
-
Abstract:
Maturity-onset diabetes of the young (MODY) is a special type of diabetes characterized by clinical features including early onset of diabetes (before 30 years of age), autosomal dominant inheritance, impaired glucose-induced insulin secretion, and hyperglycemia. So far, 14 types of MODY have been reported, accounting for about 1%-5% of the patients with diabetes. MODY often presents with an insidious onset, and although 14 subtypes have been identified for MODY, it is frequently misdiagnosed as type 1 or type 2 diabetes due to overlapping clinical features and high costs and limitations of genetic testing. This article reviews the clinical features of MODY subtypes in order to improve the accuracy of the diagnosis and treatment of MODY.
