Expression of soluble factor-related apoptosis ligand in peripheral blood and microRNA-147b in monocytes in children with sepsis and their association with prognosis.
10.7499/j.issn.1008-8830.2408152
- Author:
Jun ZHANG
1
;
Xiao-Fei LIN
1
;
Yun-Duo WU
1
;
Hong-Li ZHU
1
;
Juan LIU
1
Author Information
1. PICU, Huai'an Maternal and Child Health Hospital Affiliated to Yangzhou University, Huai'an, Jiangsu 223002, China.
- Publication Type:Journal Article
- Keywords:
Child;
Monocyte miR-147b;
Prognosis;
Sepsis;
Soluble factor-related apoptosis ligand
- MeSH:
Humans;
Sepsis/diagnosis*;
MicroRNAs/blood*;
Male;
Female;
Monocytes/metabolism*;
Prognosis;
Child, Preschool;
Prospective Studies;
Child;
Infant;
TNF-Related Apoptosis-Inducing Ligand/blood*;
Logistic Models
- From:
Chinese Journal of Contemporary Pediatrics
2025;27(1):82-87
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To investigate the expression of soluble factor-related apoptosis ligand (sFasL) in peripheral blood and microRNA-147b (miR-147b) in monocytes in children with sepsis and their value in assessing prognosis.
METHODS:A prospective study was conducted on 124 children with sepsis (sepsis group), 60 children with common infections (infection group), and 60 healthy children undergoing physical examinations (healthy control group). The independent risk factors for poor prognosis in children with sepsis were analyzed, and the value of serum sFasL and monocyte miR-147b in predicting poor prognosis in children with sepsis was assessed.
RESULTS:The serum level of sFasL and the relative expression of miR-147b in monocytes were highest in the sepsis group, followed by the infection group and the healthy control group (P<0.05). The multivariate logistic regression analysis showed that the serum level of sFasL and the relative expression of miR-147b in monocytes were closely associated with the poor prognosis of children with sepsis (P<0.05). The receiver operating characteristic curve analysis showed that the combination of serum sFasL level and relative expression of miR-147b in monocytes had a larger area under the curve compared to each indicator alone in predicting the prognosis of children with sepsis (P<0.05).
CONCLUSIONS:There are significant increases in the level of sFasL in peripheral blood and the relative expression of miR-147b in monocytes in children with sepsis. The combined use of these two indicators has relatively high clinical value in assessing the prognosis of children with sepsis.
