Growth and development patterns of Noonan syndrome and advances in the treatment of short stature.
10.7499/j.issn.1008-8830.2409047
- Author:
Xin LI
1
;
Tian WEN
1
;
Bi-Yun FENG
1
;
Xiu-Min WANG
1
Author Information
1. Department of Endocrinology, Metabolism and Genetics, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
- Publication Type:English Abstract
- Keywords:
Growth and development;
Growth hormone;
Noonan syndrome;
Short stature
- MeSH:
Noonan Syndrome/complications*;
Humans;
Body Height;
Growth Disorders/therapy*
- From:
Chinese Journal of Contemporary Pediatrics
2025;27(1):33-38
- CountryChina
- Language:Chinese
-
Abstract:
Patients with Noonan syndrome (NS) are born with normal or slightly lower body length and weight compared to the normal ranges. However, their height gradually falls behind that of the general population, leading to growth retardation and delayed puberty. In China, the incidence of short stature in patients with NS is approximately 65%. Short stature in these patients arises from multiple causes, including feeding difficulties in infancy, comorbidities such as congenital heart disease, genetic heterogeneity, and disorders of the growth hormone/insulin-like growth factor-1 axis. Growth hormone is commonly used to alleviate symptoms of short stature. This article reviews the growth and development patterns at different stages of NS, analyzes the causes of short stature, and summarizes the latest advances in treatment to provide new insights for the diagnosis and management of short stature in patients with NS.
