Outcomes and management of Peyronie's disease with combined treatment of collagenase clostridium histolyticum, vacuum erection device, and tadalafil.

Raidh Talib ALZUBAIDI; Mohamed ABDELKAREEM; Raed M AL-ZOUBI; Ahmad R AL-QUDIMAT; Aksam YASIN; Hatem KAMKOUM; Abdullah A AL-ANSARI

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Outcomes and management of Peyronie's disease with combined treatment of collagenase clostridium histolyticum, vacuum erection device, and tadalafil.

Author: Raidh Talib ALZUBAIDI ¹ ; Mohamed ABDELKAREEM ¹ ; Raed M AL-ZOUBI ² ; Ahmad R AL-QUDIMAT ² ; Aksam YASIN ¹ ; Hatem KAMKOUM ¹ ; Abdullah A AL-ANSARI ¹
Author Information

1. Department of Surgery, Division of Urology/Andrology, Aisha Bint Hamad Al Attiyah Hospital, Doha 3050, Qatar.
2. Surgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha 3050, Qatar.
Publication Type:Journal Article
Keywords: Peyronie’s disease; collagenase clostridium histolyticum; erectile dysfunction; penile curvature; tadalafil; vacuum therapy
MeSH: Humans; Male; Penile Induration/therapy*; Tadalafil/therapeutic use*; Retrospective Studies; Microbial Collagenase/administration & dosage*; Middle Aged; Vacuum; Treatment Outcome; Adult; Penile Erection; Combined Modality Therapy; Phosphodiesterase 5 Inhibitors/therapeutic use*; Aged; Erectile Dysfunction/etiology*
From: Asian Journal of Andrology 2025;27(6):686-690
CountryChina
Language:English
Abstract: Peyronie's disease (PD) is a connective tissue disorder characterized by abnormal collagen deposition in the tunica albuginea, leading to penile curvature, pain, and erectile dysfunction. This study aimed to evaluate the outcomes of a combined treatment protocol incorporating collagenase clostridium histolyticum (CCH), vacuum erection device, and tadalafil. A retrospective analysis was conducted on 99 male patients with PD treated at the Department of Urology, Hamad Medical Corporation (Doha, Qatar) between January 2018 and January 2020. Patients received 4-8 CCH injections alongside vacuum therapy and daily tadalafil (5 mg). The baseline mean penile curvature of 49.0° improved by an average of 21.4% post-treatment. Erectile function scores also increased significantly, with a mean improvement of 2.3 points on the International Index of Erectile Function. Minor complications were observed in 15 patients, while 13 were dissatisfied with treatment, with six opting for surgery. The modified protocol demonstrated significant improvements in penile curvature and erectile function with minimal complications, offering a safe, cost-effective alternative to traditional intensive treatments.