Regulation of testosterone synthesis by circadian clock genes and its research progress in male diseases.
- Author:
Gang NING
1
;
Bo-Nan LI
2
;
Hui WU
1
;
Ruo-Bing SHI
1
;
A-Jian PENG
1
;
Hao-Yu WANG
1
;
Xing ZHOU
3
Author Information
- Publication Type:Review
- Keywords: circadian clock genes; circadian rhythm; male disease; testosterone synthesis
- MeSH: Testosterone/metabolism*; Humans; Male; Circadian Clocks/genetics*; Circadian Rhythm Signaling Peptides and Proteins/metabolism*; Circadian Rhythm/physiology*; Hypogonadism/metabolism*; Erectile Dysfunction/metabolism*; Infertility, Male/metabolism*; Prostatic Neoplasms/metabolism*; Men's Health
- From: Asian Journal of Andrology 2025;27(5):564-573
- CountryChina
- Language:English
- Abstract: The circadian clock is an important internal time regulatory system for a range of physiological and behavioral rhythms within living organisms. Testosterone, as one of the most critical sex hormones, is essential for the development of the reproductive system, maintenance of reproductive function, and the overall health of males. The secretion of testosterone in mammals is characterized by distinct circadian rhythms and is closely associated with the regulation of circadian clock genes. Here we review the central and peripheral regulatory mechanisms underlying the influence of circadian clock genes upon testosterone synthesis. We also examined the specific effects of these genes on the occurrence, development, and treatment of common male diseases, including late-onset hypogonadism, erectile dysfunction, male infertility, and prostate cancer.
