Differentiation between nonobstructive azoospermia and obstructive azoospermia: then and now.

Author: Logan HUBBARD ¹ ; Amarnath RAMBHATLA ¹ ; Giovanni M COLPI ²
Author Information

1. Vattikuti Urology Institute, Henry Ford Hospital, Detroit, MI 48202-3450, USA.
2. Andrology and IVF Center, Next Fertility Procrea, Lugano 6900, Switzerland.
Publication Type:Review
Keywords: male factor infertility; nonobstructive azoospermia; obstructive azoospermia
MeSH: Humans; Azoospermia/etiology*; Male; Diagnosis, Differential; Infertility, Male/etiology*
From: Asian Journal of Andrology 2025;27(3):298-306
CountryChina
Language:English
Abstract: Male infertility has seen an increase in prevalence with cases of azoospermia estimated to affect 10%-15% of infertile men. Confirmation of azoospermia subsequently necessitates an early causal differentiation between obstructive azoospermia (OA) and nonobstructive azoospermia (NOA). Although less common when compared to NOA, OA can represent upward 20%-40% of cases of azoospermia. While there are a multitude of etiologies responsible for causing NOA and OA, correctly distinguishing between the two types of azoospermia has profound implications in managing the infertile male. This review represents an amalgamation of the current guidelines and literature which will supply the reproductive physician with a diagnostic armamentarium to properly distinguish between NOA and OA, therefore providing the best possible care to the infertile couple.