Intralesional and topical treatments for Peyronie's disease: a narrative review of current knowledge.

Antonio MINORE; Loris CACCIATORE; Fabrizio PRESICCE; Andrea IANNUZZI; Antonio TESTA; Gianluigi RASO; Rocco PAPALIA; Marco MARTINI; Roberto Mario SCARPA; Francesco ESPERTO

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Intralesional and topical treatments for Peyronie's disease: a narrative review of current knowledge.

Author: Antonio MINORE ¹ ; Loris CACCIATORE ¹ ; Fabrizio PRESICCE ² ; Andrea IANNUZZI ¹ ; Antonio TESTA ¹ ; Gianluigi RASO ¹ ; Rocco PAPALIA ¹ ; Marco MARTINI ² ; Roberto Mario SCARPA ¹ ; Francesco ESPERTO ¹
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1. Department of Urology, Campus Bio-Medico, University of Rome, Rome 00128, Italy.
2. Department of Urology, San Filippo Neri Hospital, Rome 00135, Italy.
Publication Type:Review
MeSH: Humans; Male; Administration, Topical; Botulinum Toxins/administration & dosage*; Extracorporeal Shockwave Therapy; Hyaluronic Acid/administration & dosage*; Injections, Intralesional; Interferons/administration & dosage*; Microbial Collagenase/administration & dosage*; Penile Induration/therapy*; Platelet-Rich Plasma; Stem Cell Transplantation; Traction
From: Asian Journal of Andrology 2025;27(2):156-165
CountryChina
Language:English
Abstract: Peyronie's disease (PD) presents a multifaceted challenge in contemporary urological practice, marked by penile deformity, pain, and the potential for erectile dysfunction. We meticulously explored the existing literature of intralesional/topical interventions, aiming to provide clinicians with a nuanced understanding of available options for comprehensive PD management. To conduct this review, we performed a systematic search using the PubMed, Scopus, and ScienceDirect databases, including the keywords of combination of the "Peyronie's disease/plastic induration of the penis (PIP) and intralesional/topical treatments". The study selection was based on adherence to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, resulting in the inclusion of 16 articles. We delve into the effectiveness and safety profiles of collagenase Clostridium histolyticum (CCH), interferon, platelet-rich plasma (PRP), hyaluronic acid, botulinum toxin, stem cell, extracorporeal shock wave therapy (ESWT), and traction therapy, assessing their impact on penile curvature, length improvement, and patient-reported symptoms and outcomes. The best options evaluated are intralesional injections of CCH and penile traction devices, alone or in combination. Despite PD remains a challenge for urologists, the objective of this review is to contribute to the evolving landscape of PD management, fostering informed decision-making, and personalized care for individuals grappling with this challenging condition.