Clinical predictors of successful outcomes for couples with nonobstructive azoospermic male partners undergoing micro-TESE.

Parviz K KAVOUSSI; Nazim GHERABI; Ramadan SALEH

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Clinical predictors of successful outcomes for couples with nonobstructive azoospermic male partners undergoing micro-TESE.

Author: Parviz K KAVOUSSI ¹ ; Nazim GHERABI ² ; Ramadan SALEH ³
Author Information

1. Department of Reproductive Urology, Austin Fertility and Reproductive Medicine/Westlake IVF, Austin, TX 78746, USA.
2. Department of Medicine, Algiers 1 University, Algiers 16000, Algeria.
3. Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Sohag 83534, Egypt.
Publication Type:Review
Keywords: intracytoplasmic sperm injection; microdissection testicular sperm extraction; nonobstructive azoospermia
MeSH: Humans; Azoospermia/surgery*; Male; Sperm Injections, Intracytoplasmic; Sperm Retrieval; Treatment Outcome; Testis/pathology*; Female; Microdissection
From: Asian Journal of Andrology 2025;27(3):365-369
CountryChina
Language:English
Abstract: Nonobstructive azoospermia (NOA) is the most challenging and complex clinical scenario for infertile men. Besides circumstances such as hypogonadotropic hypogonadism, surgical sperm retrieval is typically necessary, and microdissection testicular sperm extraction (micro-TESE) is the procedure of choice for men with NOA desiring to father children with their own gametes. Micro-TESE results in the highest numbers of sperm cells retrieved for use with in vitro fertilization/intracytoplasmic sperm injection (ICSI) in comparison to all other techniques for surgical sperm retrieval in men with NOA. Several factors may affect sperm retrieval rate and ICSI outcomes, including the patient's age, testicular volume, histopathological and genetic profile, and serum hormone levels. This article aims to review the medical literature describing predictors of successful micro-TESE and the outcomes of ICSI in men with NOA.