Research progress in the mechanism and treatment of post traumatic platelet dysfunction.
- Author:
Kai LI
1
;
Peixin WANG
1
;
Kun WEI
1
;
Jia LIU
1
;
Xue BAI
1
;
Tiantao ZHANG
2
;
Chen ZHANG
3
;
Shihong XU
4
Author Information
1. Emergency Center (Trauma Center), Gansu Provincial Hospital of traditional Chinese medicine, Lanzhou 730050, China.
2. Clinical College of Chinese Medicine, Gansu University of traditional Chinese medicine, Lanzhou 730000, China.
3. Clinical College of Chinese Medicine, Gansu University of traditional Chinese medicine, Lanzhou 730000, China. *Corresponding authors, E-mail: 2253017475@qq.com.
4. Emergency Center (Trauma Center), Gansu Provincial Hospital of traditional Chinese medicine, Lanzhou 730050, China. *Corresponding authors, E-mail: 308359102@qq.com.
- Publication Type:English Abstract
- MeSH:
Humans;
Wounds and Injuries/therapy*;
Blood Platelets/metabolism*;
Blood Platelet Disorders/etiology*;
Animals;
Hemostasis
- From:
Chinese Journal of Cellular and Molecular Immunology
2025;41(11):1041-1046
- CountryChina
- Language:Chinese
-
Abstract:
Trauma is the main cause of death and disability. Patients with severe trauma have hemorrhagic shock, traumatic coagulopathy and other diseases, which increase the risk of death. Platelets are important in the hemostatic response, but their function is rapidly dysregulated in trauma patients, leading to traumatic coagulopathy, blood loss, and early death. In addition to their role in hemostasis, platelets act as coordinators of the initial immune response, which can lead to immunothrombosis, organ dysfunction, and increased late mortality. At present, the treatment of post traumatic platelet dysfunction is mainly based on early hemostasis, and late prevention and treatment of thrombosis and organ dysfunction. In this review, the characteristics, underlying mechanisms, diagnosis and treatment strategies of platelet dysfunction in different periods are summarized, to provide ideas for studying the mechanism of platelet dysfunction after trauma and the treatment strategy for trauma patients.
