Research progress on the effect and mechanism of NLRP3 inflammasome in head and neck squamous cell carcinoma.
- Author:
Min ZHANG
1
;
Nini ZHANG
2
,
3
;
Guilin HUANG
4
;
Zhuangzhuang LI
1
;
Hao ZHANG
1
;
Yuqi WU
5
Author Information
1. Department of Maxillofacial Surgery, Stomatological Hospital Affiliated to Zunyi Medical University, Zunyi 563003, China.
2. Department of Maxillofacial Surgery, Stomatological Hospital Affiliated to Zunyi Medical University, Zunyi 563003, China. *Corresponding author, E-mail: kqzhangni@
3. com.
4. Department of Stomatology, The Fifth Affiliated (Zhuhai) Hospital of Zunyi Medical University, Zhuhai 519180, China.
5. Department of Stomatology, The Central Hospital of Shaoyang, Shaoyang 422000, China.
- Publication Type:English Abstract
- MeSH:
Humans;
NLR Family, Pyrin Domain-Containing 3 Protein/genetics*;
Inflammasomes/metabolism*;
Head and Neck Neoplasms/pathology*;
Squamous Cell Carcinoma of Head and Neck/metabolism*;
Tumor Microenvironment;
Signal Transduction;
Animals
- From:
Chinese Journal of Cellular and Molecular Immunology
2025;41(11):1025-1033
- CountryChina
- Language:Chinese
-
Abstract:
The NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, a high-molecular-weight protein complex in the cytoplasm, is composed of three core components: the sensor protein NLRP3, the adaptor protein apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC) and the effector protein caspase-1. It plays a critical role in regulating host immune and inflammatory responses. Studies have shown that the NLRP3 inflammasome has increasingly become a focal point in tumor molecular biology field. A growing body of evidence indicates that the increased expression and activation of the NLRP3 inflammasome is closely associated with the pathogenesis of head and neck squamous cell carcinoma (HNSCC) and the tumor microenvironment (TME). It may promote tumor proliferation, invasion, migration, and other biological behaviors through various regulatory mechanisms while influencing tumor immune evasion and therapy resistance, which holds promise as a prognostic biomarker for patients. This review explores the current effect and mechanism of the NLRP3 inflammasome and its signaling pathways in head and neck cancer, providing insights into clinical targeted drug development and molecular immunotherapy.
