PANoptosis: A novel perspective on the pathogenesis of ovarian hypofunction.
- Author:
Can ZHU
1
;
Jinhong LI
1
;
Tianqi CHEN
1
;
Fang PENG
2
Author Information
1. Department of Physiology, College of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China.
2. Department of Physiology, College of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China. *Corresponding author, E-mail: pengfang326@gzy.edu.cn.
- Publication Type:English Abstract
- MeSH:
Humans;
Female;
Ovary/metabolism*;
Apoptosis;
Animals;
Necroptosis;
Ovarian Diseases/physiopathology*
- From:
Chinese Journal of Cellular and Molecular Immunology
2025;41(11):1020-1024
- CountryChina
- Language:Chinese
-
Abstract:
PANoptosis, a newly defined form of cell death, is characterized by the simultaneous occurrence and crosstalk of apoptosis, pyroptosis, and necroptosis. It has emerged as a promising therapeutic target for various diseases. Ovarian dysfunction is marked by oligomenorrhea or amenorrhea, elevated gonadotropin levels, and diminished estrogen levels, often accompanying subfertility or infertility. Additionally, it can manifest with perimenopausal syndrome and increase the risks of osteoporosis, cardiovascular disease, and cognitive impairments, seriously impacting patients' quality of life. While current studies have reported that ovarian hypofunction is associated with apoptosis, pyroptosis, or necroptosis, a systematic investigation into the relationship between PANoptosis and ovarian hypofunction is still absent. This review aims to elucidate the potential link between these two phenomena, providing new insights into the mechanisms underlying ovarian hypofunction and potential treatment strategies.
