Research on the anti-inflammatory effects of a novel sleep-aid decoction on elderly insomnia patients across traditional Chinese medicine constitutional types.
- Author:
Zhen WU
1
;
Zhuoqiong BIAN
2
;
Ailin CHEN
3
;
Qiuping ZHANG
4
;
Jie LI
2
;
Hui ZHOU
4
;
Hongying ZHU
5
Author Information
1. Department of Rheumatology and Immunology Ward No.6, Xi'an No. 5 Hospital, Xi'an 710082, China.
2. Pre-disease Treatment Department, Xi'an No. 5 Hospital, Xi'an 710082, China.
3. Department of Rheumatology and Immunology Ward No.8, Xi'an No. 5 Hospital, Xi'an 710082, China.
4. Department of Geriatrics, Xi'an No. 5 Hospital, Xi'an 710082, China.
5. Hospital Administration Office, Xi'an No. 5 Hospital, Xi'an 710082, China. *Corresponding author, E-mail: 623004649@qq.com.
- Publication Type:Journal Article
- MeSH:
Humans;
Sleep Initiation and Maintenance Disorders/blood*;
Aged;
Male;
Female;
Drugs, Chinese Herbal/therapeutic use*;
Medicine, Chinese Traditional;
Middle Aged;
Tumor Necrosis Factor-alpha/blood*;
Sleep Aids, Pharmaceutical/therapeutic use*;
Anti-Inflammatory Agents/therapeutic use*;
Interleukin-6/blood*;
Interleukin-1beta/blood*;
Neurotransmitter Agents/blood*;
Aged, 80 and over;
C-Reactive Protein/metabolism*
- From:
Chinese Journal of Cellular and Molecular Immunology
2025;41(11):1007-1012
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of a novel sleep-aid decoction in treating elderly insomnia patients with different traditional Chinese medicine (TCM) constitutional types, and its effects on neurotransmitter and inflammatory factor levels. Methods A total of 200 patients with four different TCM constitutions-peaceful, Qi-deficient, Yin-deficient, and Yang-deficient-were recruited. Peripheral blood neurotransmitter and inflammatory factor levels were measured for variations among insomnia patients across different constitutions. These patients were treated using the novel sleep-aid decoction, the effects of which were evaluated based on changes in neurotransmitters and inflammatory factors. Results Compared to the peaceful constitution group, insomnia patients with Qi-deficient, Yin-deficient, and Yang-deficient constitutions exhibited significantly elevated baseline levels of neurotransmitters (5-HT, GABA) and inflammatory factors (IL-6, TNF-α, IL-1β, CRP). Following the treatment, the Qi-deficient and Yin-deficient groups showed a marked increase in 5-HT levels, restored balance of Glu, GABA, and melatonin, and significant reductions in IL-6 and TNF-α levels. The overall effective rate was 83.5%, with optimal efficacy observed in the Qi-deficient (97.72%) and Yin-deficient (95.34%) groups. Conclusion The novel sleep-aid decoction is effective in treating insomnia in elderly patients, with the best results observed in the Qi-deficient and Yin-deficient constitution groups.
