Ferroptosis: from molecules to diseases.
- Author:
Xuesong WANG
1
;
Di KANG
1
;
Yingying WANG
1
;
Ye SHAO
1
;
Hongbo LI
2
Author Information
1. Department of Respiratory and Critical Care Medicine, the Affiliated Hospital of Binzhou Medical University (The First Clinical Medical College), Binzhou 256603, China.
2. Department of Respiratory and Critical Care Medicine, the Affiliated Hospital of Binzhou Medical University (The First Clinical Medical College), Binzhou 256603, China. *Corresponding author, E-mail: lihongbo0516@sina.com.
- Publication Type:English Abstract
- MeSH:
Humans;
Ferroptosis/physiology*;
Iron/metabolism*;
Animals;
Neoplasms/metabolism*;
Neurodegenerative Diseases/metabolism*
- From:
Chinese Journal of Cellular and Molecular Immunology
2025;41(10):937-953
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a regulated form of cell death, with its core mechanism being intracellular iron overload-induced lipid peroxidation, leading to cellular dysfunction and mitochondrial structural abnormalities. Ferroptosis is closely related to various diseases including neurodegenerative disorders, tumors, and ischemia-reperfusion organ damage, and has become a potential therapeutic target. Iron is essential for life but can also cause cell death. Despite continuous progress in iron-related biomedical research, many questions remain unanswered. Advances in high-throughput technologies, genomics and proteomics are expected to reveal the cellular iron regulatory mechanism and open up new therapeutic approaches for ferroptosis-related diseases. This article reviews the research progress on iron in terms of its biology, metabolism, regulation, and related diseases, aiming to provide clues and references for developing new ferroptosis-targeted therapeutic strategies and facilitating more in-depth molecular studies from multiple perspectives.
