The role of NLRP3 inflammasome in the pathogenesis of lupus nephritis and research progress.
- Author:
Qianyu WANG
1
;
Meitong CHEN
1
;
Zhaoan GUO
2
,
3
Author Information
1. The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250014, China.
2. Nephrology Department, The Affiliated Hospital, Shandong University of Traditional Chinese Medicine, Jinan 250014, China. *Corresponding author, E-mail: gza63@
3. com.
- Publication Type:English Abstract
- MeSH:
Humans;
Lupus Nephritis/etiology*;
NLR Family, Pyrin Domain-Containing 3 Protein/metabolism*;
Inflammasomes/immunology*;
Animals
- From:
Chinese Journal of Cellular and Molecular Immunology
2025;41(10):929-936
- CountryChina
- Language:Chinese
-
Abstract:
Lupus nephritis (LN), one of the most severe complications of systemic lupus erythematosus (SLE), has a complex pathogenesis involving various endogenous factors including autoimmune complex deposition, inflammatory cell infiltration, and cellular damage. Recent research has increasingly highlighted the prominent role of inflammasomes, particularly the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome, in LN pathogenesis. Substantial evidence has confirmed its significant role in both the onset and progression of LN. Given that the NLRP3 inflammasome is a critical factor in triggering and exacerbating LN, its mechanism of action warrants in-depth exploration. Furthermore, research on intervention strategies targeting the NLRP3 inflammasome to ameliorate LN is of great significance. This article reviews the latest advances in the role of the NLRP3 inflammasome in LN pathogenesis and related intervention studies, which may offer new insights for the clinical diagnosis and treatment of LN.
