The role of CD8+ regulatory T cell in the pathogenesis of rheumatoid arthritis.
- Author:
Lichun BAI
1
;
Hongbin LI
1
;
Jing WANG
2
,
3
Author Information
1. Department of Rheumatology and Immunology, The Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Key Laboratory for Pathogenesis and Immunodiagnosis of Rheumatic and Autoimmune Diseases, Key Laboratory of Autoimmunity and Rheumatology, Inner Mongolia Medical University, Hohhot 010050, China.
2. Department of Rheumatology and Immunology, The Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Key Laboratory for Pathogenesis and Immunodiagnosis of Rheumatic and Autoimmune Diseases, Key Laboratory of Autoimmunity and Rheumatology, Inner Mongolia Medical University, Hohhot 010050, China.*Corresponding author, E-mail: wangjing20059@
3. com.
- Publication Type:English Abstract
- MeSH:
Arthritis, Rheumatoid/pathology*;
Humans;
T-Lymphocytes, Regulatory/immunology*;
CD8-Positive T-Lymphocytes/immunology*;
Animals
- From:
Chinese Journal of Cellular and Molecular Immunology
2025;41(9):851-857
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis (RA) is an autoimmune disease characterized by complex pathogenesis, with its development closely linked to immune dysregulation. Regulatory T cells (Tregs), as specialized immunomodulatory cells, play a pivotal role in negatively regulating immune responses and maintaining autoimmune tolerance. In recent years, extensive research has focused on the relationship between Tregs and RA pathogenesis, with the functional role of CD8+ Tregs as a critical area of investigation. This review summarizes the alterations in CD8+ Tregs during RA progression and their potential mechanisms of action. By elucidating the diversity of CD8+ Treg subsets and their intricate roles in modulating immune responses, this analysis provides novel insights and therapeutic strategies for RA diagnosis and treatment.
