Research progress on the role of macrophages in neutrophilic asthma.
- Author:
Hongnian LU
1
;
Yuting WU
1
;
Tingting WANG
1
;
Rong GAO
2
,
3
;
Weizhen QIAO
4
Author Information
1. Department of Laboratory Medicine, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi 214023, China.
2. Department of Laboratory Medicine, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi 214023, China. *Corresponding authors, E-mail: higaorong@
3. com.
4. Department of Laboratory Medicine, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi 214023, China. *Corresponding authors, E-mail: qiaowz@foxmail.com.
- Publication Type:English Abstract
- MeSH:
Humans;
Asthma/pathology*;
Neutrophils/pathology*;
Macrophages/immunology*;
Animals;
Phagocytosis
- From:
Chinese Journal of Cellular and Molecular Immunology
2025;41(9):837-843
- CountryChina
- Language:Chinese
-
Abstract:
Asthma is a chronic inflammatory disease of the airway involving various cellular players. Among the different phenotypes of asthma, neutrophilic asthma is often associated with severe airway inflammation and a notable resistance to corticosteroid treatment. Macrophages, as innate immune cells, play a crucial role in the pathogenesis of neutrophilic asthma. They regulate neutrophil recruitment and activation to promote the progression of airway inflammation. During this process, macrophages also undergo changes in aspects such as efferocytosis. We reviewed the recent research progresses regarding the role of macrophages in the pathogenesis of neutrophilic asthma, aiming to provide valuable insights for future studies in this area.
