Current research on severe combined immunodeficiency with transplacental maternal engraftmentt.
- Author:
Wenyan LI
1
;
Kuimiao DENG
1
;
Guangyuan YU
1
;
Kang ZHU
2
,
3
Author Information
1. Department of Respiratory Disease, Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
2. Department of Respiratory Disease, Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China. *Corresponding author, E-mail: zhukang102@
3. com.
- Publication Type:English Abstract
- MeSH:
Humans;
Severe Combined Immunodeficiency/diagnosis*;
Pregnancy;
Female;
Hematopoietic Stem Cell Transplantation/adverse effects*;
Maternal-Fetal Exchange/immunology*;
Graft vs Host Disease/etiology*;
Animals;
Placenta/immunology*
- From:
Chinese Journal of Cellular and Molecular Immunology
2025;41(9):832-836
- CountryChina
- Language:Chinese
-
Abstract:
Severe combined immunodeficiency (SCID) represents a group of genetically heterogeneous disorders characterized by mutations that lead to profound defects in both humoral and cellular immunity. Transplacental maternal engraftment (TME) is a frequently observed complication in SCID. While most cases of SCID with TME exhibit no substantial impact on disease progression, a subset of patients may encounter diagnostic delays or therapeutic challenges due to TME interference. Furthermore, TME may predispose these individuals to graft-versus-host disease (GVHD) prior to hematopoietic stem cell transplantation, thereby increasing diagnostic complexity and treatment risks. This review systematically examines the etiology and clinical manifestations of SCID associated with TME, analyzes its implications for disease management, and evaluates current detection methodologies. The synthesized evidence provides a theoretical foundation for future research and offers potential insights into the clinical diagnosis and management of SCID associated with TME.
