Research progress on the role of viral infection-regulated mitophagy in the regulation of immune response.
- Author:
Xiaoying DENG
1
;
Chao FAN
2
;
Ying ZHANG
3
Author Information
1. Xi'an Medical University, Xi'an 710021; Department of Infectious Diseases, Tangdu Hospital, Air Force Medical University, Xi'an 710038, China.
2. Department of Infectious Diseases, Tangdu Hospital, Air Force Medical University, Xi'an 710038, China.
3. Department of Infectious Diseases, Tangdu Hospital, Air Force Medical University, Xi'an 710038, China. *Corresponding author, E-mail: zyfmmu@hotmail.com.
- Publication Type:English Abstract
- MeSH:
Mitophagy/immunology*;
Humans;
Animals;
Virus Diseases/immunology*;
Mitochondria/metabolism*;
Immunity, Innate;
Adaptive Immunity
- From:
Chinese Journal of Cellular and Molecular Immunology
2025;41(9):827-831
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondria are one of the oldest and most important endomembrane systems in eukaryotic cells and serve as the hubs of multiple cellular processes. Mitophagy (mitochondrial autophagy), a major way to maintain mitochondrial homeostasis, is closely linked to antiviral immune regulation. Depending on whether ubiquitination is required for the involved receptors or adaptors, mitophagy can be classified into ubiquitin-dependent and ubiquitin-independent types. Viruses can directly or indirectly regulate mitophagy and mitochondrial dynamics through various pathways. Through these processes, they can affect innate and adaptive immunity, so as to achieve immune escape, aggravate cell damage or promote the formation of adaptive immunity. This review summarizes the latest research progress on the role of viral infection-regulated mitophagy in the regulation of immune response.
