The expression characteristics of TXN in pan cancer and its impact on tumor immunity and prognosis.
- Author:
Annan SUN
1
;
Luna SUN
2
;
Hao WU
1
;
Pu LI
3
Author Information
1. Clinical College of Central Hospital of Obstetrics and Gynecology, Tianjin Medical University, Tianjin 300000; Department of Gynecology, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin 300052, China.
2. Department of Gynecology, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin 300052; School of Medicine, Nankai University, Tianjin 300071, China.
3. Department of Gynecology, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin 300052, China. *Corresponding author, E-mail: 2326791@qq.com.
- Publication Type:Journal Article
- MeSH:
Humans;
Prognosis;
Neoplasms/diagnosis*;
Thioredoxins/metabolism*;
Microsatellite Instability;
Gene Expression Regulation, Neoplastic;
Biomarkers, Tumor/genetics*;
Mutation;
Tumor Microenvironment
- From:
Chinese Journal of Cellular and Molecular Immunology
2025;41(8):706-716
- CountryChina
- Language:Chinese
-
Abstract:
Objective TXN is a thioredoxin (TXN) that participates in many redox reactions and plays a crucial role in various signaling pathways. However, the role of TXN in many cancers is still unclear. The objective of this study is to investigate and visualize the diagnostic, prognostic, and immunological implications of TXN expression across various cancer types. Methods The clinical data were downloaded from the cancer genome mapping project(TCGA) database to analyze the expression level of TXN in pan cancer, and the expression level was preliminarily verified by human protein mapping (HPA)(https://www.proteinatlas.org/)database. The ESTIMATE algorithm and CIBERSORT algorithm were applied to calculate the correlation between TXN expression and immune cell infiltration. The correlation between TXN and microsatellite instability (MSI) and tumor mutation burden (TMB) was analyzed using Spearman method. Gene Set Enrichment Analysis (GSEA) is used for gene biology functional analysis and sensitivity analysis of genes to pan cancer therapeutic drugs. Results TXN is highly expressed in most malignant tumors. The high expression of TXN is associated with overall survival (OS), disease-specific survival (DSS), disease-free interval (DFI), and progression free interval (PFI) in various cancers. Moreover, TXN expression is associated with TMB, MSI, tumor microenvironment, chemotherapy sensitivity and so on. Conclusion TXN may become a potential prognostic biomarker in pan cancer, providing strong theoretical basis for future tumor diagnosis and prognosis judgment. The retinoic acid-inducible gene-I (RIG-I)-like receptor signaling pathway, Toll-like receptor (TLR) signaling pathway, and nucleotide binding oligomerization domain (NOD)-like receptor signaling pathway may be crucial pathways through which TXN influences tumor immunity.
