Study on the correlation between MASP-2 and diseases.
- Author:
Yu CAO
1
;
Yan ZHOU
2
;
Tianjun JIA
3
Author Information
1. Key Laboratory of Clinical Laboratory Diagnostics, Hebei North University, Zhangjiakou 075000, China.
2. Institute of Pathogenic Biology and Immunology, Hebei North University, Zhangjiakou 075000, China.
3. Key Laboratory of Clinical Laboratory Diagnostics, Hebei North University, Institute of Pathogenic Biology and Immunology, Hebei North University, Zhangjiakou 075000, China. *Corresponding author, E-mail: 452871832@qq.com.
- Publication Type:English Abstract
- MeSH:
Humans;
Mannose-Binding Protein-Associated Serine Proteases/metabolism*;
Neoplasms/metabolism*;
Autoimmune Diseases/genetics*;
Animals;
Polymorphism, Genetic;
Communicable Diseases/genetics*
- From:
Chinese Journal of Cellular and Molecular Immunology
2025;41(7):661-666
- CountryChina
- Language:Chinese
-
Abstract:
Mannose-binding lectin-associated serine protease 2(MASP-2) is a member of serine protease family and plays a crucial role in activating the complement lectin pathway. When mannose residues on the surface of a pathogen are recognized by mannose-binding lectins (MBL) or fibrinogen collagen (FCN), MASP-2 is activated. This activation then triggers the cleavage of C4 and C2 to form C3 convertase, thereby initiating the lectin pathway of the complement system. Numerous studies have demonstrated that MASP-2 gene polymorphisms and serum levels are closely related with various diseases, including tumors, infectious diseases, autoimmune diseases and so on. In this review, we summarize the relationships between MASP-2 and tumors, infectious diseases, autoimmune diseases. We aim to provide a theoretical basis for the early diagnosis, prognosis evaluation and clinical treatment of various diseases.
