The role of cytokines in Chlamydia-induced inflammation.
- Author:
Tianai CAO
1
;
Yan ZHOU
1
;
Tianjun JIA
2
Author Information
1. Institute of Pathogenic Biology and Immunology, Key Laboratory of Clinical Laboratory Diagnostics, Hebei North University, Zhangjiakou 075000, China.
2. Institute of Pathogenic Biology and Immunology, Key Laboratory of Clinical Laboratory Diagnostics, Hebei North University, Zhangjiakou 075000, China. *Corresponding author, E-mail: 452871832@qq.com.
- Publication Type:English Abstract
- MeSH:
Humans;
Cytokines/metabolism*;
Chlamydia Infections/microbiology*;
Animals;
Inflammation/microbiology*;
Chlamydia/immunology*
- From:
Chinese Journal of Cellular and Molecular Immunology
2025;41(6):564-570
- CountryChina
- Language:Chinese
-
Abstract:
Chlamydia is an obligate intracellular pathogen that causes a wide range of diseases in humans and animals. Chlamydia infection often causes inflammatory response of the body, which seriously affects the health of the host. Cytokines, as key molecules of immune regulation, play an important role in Chlamydia-induced inflammation. Proinflammatory cytokines, such as tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), IL-6 and interferon γ (IFN-γ), are rapidly activated in the early stage of Chlamydia-induced infection, participating in the recruitment of immune cells to the site of infection and initiating inflammatory response; IL-10 and transforming growth factor β (TGF-β) regulate the activation and function of immune cells in the late stage of inflammation, thus affecting the development of inflammation. There are complex interactions and regulatory mechanisms among cytokines. This review summarizes the role of cytokines in Chlamydia-induced inflammation, and provides an important theoretical basis for the diagnosis and treatment of Chlamydia infection related diseases and the development of vaccines.
