Recent progress in the regulation of cellular immunity to erythrocyte homologous immunity.
- Author:
Woxia HONG
1
;
Changlin WU
2
;
Chaopeng SHAO
3
Author Information
1. Guangdong Medical University, Shenzhen Bao'an Clinical Medical College, Shenzhen 518000, China.
2. Guangdong Medical University, Zhanjiang 524023, China.
3. Guangdong Medical University, Zhanjiang 524023, China. *Corresponding author, E-mail: cpshaos@hotmail.com.
- Publication Type:English Abstract
- MeSH:
Humans;
Immunity, Cellular/immunology*;
Erythrocytes/immunology*;
Blood Group Antigens/immunology*;
Animals;
Isoantibodies/immunology*;
T-Lymphocytes/immunology*
- From:
Chinese Journal of Cellular and Molecular Immunology
2025;41(6):559-563
- CountryChina
- Language:Chinese
-
Abstract:
Chronic anemia patients (such as thalassemia) often rely on long-term red blood cell transfusion to sustain life. However, alloimmune reactions against blood group antigens can pose serious risks to the patients' clinical treatment and survival. The regulatory mechanisms of transfusion-related alloimmunity are not yet well understood. For example, some patients, despite long-term transfusions, do not develop alloimmune reactions, while others produce alloantibodies against multiple blood group antigens, making transfusion therapy increasingly difficult. Red blood cell blood group alloimmunity involves various immune cells, including antigen-presenting cells and different T cells. Many studies are exploring the regulatory roles and even potential interventions. This article reviews the correlation between cellular immunity and red blood cell blood group antigens in alloimmune responses, and explores the interaction between the two, as well as their impact on immune responses.
