Research progress on central memory T cells.
- Author:
Junwei HUANG
1
;
Wei LU
1
;
Jingxin YAO
1
;
Hanwei DENG
2
;
Ji BIN
2
;
Yuexiang MA
2
;
Zhenhua ZHU
3
,
4
Author Information
1. Hunan University of Chinese Medicine, Changsha 410208, China.
2. Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410007, China.
3. Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410007, China. *Corresponding author, E-mail: zhenhua787@
4. com.
- Publication Type:English Abstract
- MeSH:
Humans;
Memory T Cells/cytology*;
Animals;
Immunologic Memory;
Neoplasms/therapy*;
Immunotherapy
- From:
Chinese Journal of Cellular and Molecular Immunology
2025;41(5):468-474
- CountryChina
- Language:Chinese
-
Abstract:
Central memory T (Tcm) cells are a crucial subset in T cell development, playing an important role in long-term immune responses. Tcm cells exhibit strong proliferative capacity, long-term survival characteristics, and re-activation potential, enabling them to rapidly differentiate into effector T cells (Teff) upon antigen re-exposure, thus providing robust immune protection. The function of Tcm cells is regulated by various factors, including antigen exposure, cytokines, and metabolic conditions. A deeper understanding of their metabolic and epigenetic mechanisms under different pathological conditions will contribute to the development of more precise and effective immunotherapeutic strategies. This review elaborates on the origin and characteristics of Tcm cells, as well as their roles in antiviral responses, tumor immunity, and immunotherapy.
