Sialyltransferase ST3GAL1 promotes malignant progression in glioma.
- Author:
Zihao ZHAO
1
;
Wenjing ZHENG
2
;
Lingling ZHANG
2
;
Wenjie SONG
3
;
Tao WANG
4
Author Information
1. Department of Hepatobiliary Surgery, Affiliated Xijing Hospital, Air Force Medical University, Xi'an 710032, China.
2. Department of Medical Genetics and Developmental Biology, Basic Medical Science Academy, Air Force Medical University, Xi'an 710032, China.
3. Department of Hepatobiliary Surgery, Affiliated Xijing Hospital, Air Force Medical University, Xi'an 710032, China. *Corresponding authors, E-mail: wjsong@fmmu.edu.cn.
4. Department of Medical Genetics and Developmental Biology, Basic Medical Science Academy, Air Force Medical University, Xi'an 710032, China. *Corresponding authors, E-mail: wangt@fmmu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Humans;
Sialyltransferases/metabolism*;
Glioma/diagnosis*;
Cell Proliferation/genetics*;
Cell Line, Tumor;
Brain Neoplasms/enzymology*;
beta-Galactoside alpha-2,3-Sialyltransferase;
Disease Progression;
Prognosis;
Cell Movement/genetics*;
Apoptosis/genetics*;
Male;
Female;
Gene Expression Regulation, Neoplastic;
Biomarkers, Tumor/metabolism*;
Middle Aged
- From:
Chinese Journal of Cellular and Molecular Immunology
2025;41(4):308-317
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical relevance and diagnostic or prognostic value of ST3β-galactoside α-2, 3-sialyltransferase 1 (ST3GAL1) in glioma and to confirm its role in promoting malignant phenotypes. Methods Using data from The Cancer Genome Atlas (TCGA) database, we analyzed the correlation between ST3GAL1 expression levels in glioma and clinical parameters to evaluate its diagnostic and prognostic value. The impact of ST3GAL1 on malignant phenotypes of glioma cells-including proliferation, cell cycle progression, apoptosis, and invasion was further validated through ST3GAL1 knockdown experiments. Results The expression level of ST3GAL1 was significantly higher in glioma tissues compared to healthy brain tissues and showed a strong correlation with clinical characteristics of glioma patients. Survival analysis and receiver operating characteristic (ROC) curve demonstrated that ST3GAL1 could serve as a potential diagnostic and prognostic biomarker for glioma. Knockdown of ST3GAL1 suppressed proliferation, invasion, and migration capabilities of glioma cell lines, and induced G1-phase cell cycle arrest. Conclusion ST3GAL1 promotes malignant phenotypes in glioma and plays a critical role in its malignant progression, suggesting its potential as a biomarker for glioma diagnosis and prognosis.
