Research progress in the comparison and application of mouse models with systemic lupus erythematosus.
- Author:
Jiahui XIAN
1
;
Yan XING
2
Author Information
1. Department of Clinical Biochemistry, School of Medical Lab Science, North Sichuan Medical College, Nanchong 637000, China.
2. Department of Clinical Biochemistry, School of Medical Lab Science, North Sichuan Medical College, Clinical laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China. *Corresponding author, E-mail: xingy@nsmc.edu.cn.
- Publication Type:Comparative Study
- MeSH:
Animals;
Lupus Erythematosus, Systemic/immunology*;
Disease Models, Animal;
Mice;
Humans
- From:
Chinese Journal of Cellular and Molecular Immunology
2025;41(3):262-270
- CountryChina
- Language:Chinese
-
Abstract:
Systemic lupus erythematosus (SLE) is a complex autoimmune disease with diverse clinical symptoms, which involves multiple systems and organs such as the kidney, cardiovascular system, and nervous system. The main characteristic of SLE is the mistaken attacks on self-tissues by the immune system, but the specific pathogenesis is still unclear. This paper reviews and compares the modeling mechanisms and main pathological manifestations of spontaneous and experimental mouse models of SLE, which can provide evidences for selecting appropriate mouse models in studies on the pathogenesis, clinical diagnosis and treatment of SLE.
