Analysis of clinical value of platelet antibody screening in 95 987 inpatients.
- Author:
Ping CHEN
1
;
Yang SUN
2
;
Xiaoyue CHU
3
;
Fenfang TIAN
2
;
Yingqun YANG
2
;
Wenhua WANG
2
;
Jiameng NIU
2
;
Boya ZHAO
1
;
Jingyan CHANG
2
;
Jiangcun YANG
4
;
Chaofeng MA
5
Author Information
1. Shaanxi University of Chinese Medicine, Xianyang 712046, China.
2. Department of Blood Transfusion, Shaanxi Provincial People's Hospital, Xi'an 710068, China.
3. Shaanxi Blood Center, Xi'an 710061, China.
4. Department of Blood Transfusion, Shaanxi Provincial People's Hospital, Xi'an 710068, China. *Corresponding authors, E-mail: yjc65@sina.com.
5. Shaanxi University of Chinese Medicine, Xianyang 712046; Shaanxi Blood Center, Xi'an 710061, China. *Corresponding authors, E-mail: mark7447@xiancdc.cn.
- Publication Type:Journal Article
- MeSH:
Humans;
Female;
Male;
Adult;
Middle Aged;
Blood Platelets/immunology*;
Inpatients;
Aged;
Pregnancy;
Young Adult;
Adolescent;
Aged, 80 and over;
Autoantibodies/blood*
- From:
Chinese Journal of Cellular and Molecular Immunology
2025;41(2):143-147
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the distribution of platelet antibodies in hospitalized patients and explore the clinical significance of platelet antibody detection. Methods A total of 95 987 hospitalized patient cases from a tertiary hospital in Xi'an from April 1, 2021 to December 31, 2023 were collected. Platelet antibodies were detected by solid-phase agglutination method. Statistical analysis was performed on variables including gender, age, blood type, department, history of blood transfusion, pregnancy history, and disease type. Results Among 95 987 hospitalized patients, the positive rate of platelet antibody detection reached 4.35%. The positive rate of platelet antibodies in female hospitalized patients (5.29%) was higher than that in male patients (3.31%), and the difference was statistically significant (x2=224.124). The positive rate of platelet antibodies in those with pregnancy history (7.92%) was higher than that in those without pregnancy history (4.19%), and the difference was significant (x2=292.773). Similarly, the positive rate of platelet antibodies in those with transfusion history (7.79%) was higher than that in those without transfusion history (3.97%), and the difference was significant (x2=300.209). There was a significant correlation between the positive rate of platelet antibodies and the number of pregnancies (x2=91.061). Conclusion The positive rate of platelet antibodies in 95 987 inpatient cases was 4.35%. The positive rate of platelet antibodies had a close relationship with a history of blood transfusions and pregnancies, and it increased with the number of pregnancies. For patients with multiple transfusion histories and pregnancy histories, screening for platelet antibodies holds significant diagnostic value.
