A Review of progresses in research on delayed resistance to EGFR-TKI by Traditional Chinese medicine via inhibiting cancer stem cells properties.
- Author:
Lei LIU
1
;
Zhenxiang LI
2
;
Yang LI
3
;
Haiyong WANG
4
;
Jiamao LIN
5
,
6
Author Information
1. Basic Teaching and Research Office of Traditional Chinese Medicine, College of Integrated Traditional Chinese and Western Medicine, Jining Medical University, Jining 272067, China.
2. Department of Chest Radiotherapy, Shandong First Medical University Affiliated Cancer Hospital, Jinan 250117, China.
3. Radioimmunoassay and Molecular Imaging Laboratory, Shandong First Medical University Affiliated Cancer Hospital, Jinan 250117, China.
4. Department of Internal Medicine, Shandong First Medical University Affiliated Cancer Hospital, Jinan 250117, China.
5. Department of Integrated Traditional Chinese and Western Medicine, Shandong First Medical University Affiliated Cancer Hospital, Jinan 250117, China. *Corresponding author, E-mail: linjiamao_@
6. com.
- Publication Type:English Abstract
- MeSH:
Humans;
Neoplastic Stem Cells/metabolism*;
Drug Resistance, Neoplasm/drug effects*;
ErbB Receptors/genetics*;
Protein Kinase Inhibitors/therapeutic use*;
Medicine, Chinese Traditional;
Neoplasms/drug therapy*;
Animals;
Drugs, Chinese Herbal/therapeutic use*
- From:
Chinese Journal of Cellular and Molecular Immunology
2025;41(1):77-82
- CountryChina
- Language:Chinese
-
Abstract:
It has been popular and challenging to undertake researches on the delay of acquired resistance of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI). As key cells for tumor initiation, cancer stem cells (CSC) play an important role in the process of resistance to EGFR-TKI. Although preliminary studies found that traditional Chinese medicine (TCM) could inhibit CSC properties and delay EGFR-TKI resistance, the specific molecular mechanism remains unclear. By summarizing the empirical syndrome treatment of EGFR-TKI resistance via TCM and combining recent researches on TCM intervention in CSC to delay EGFR-TKI resistance, this review discussed the potential molecular pathways and mechanisms of deceleration in resistance to EGFR-TKI by TCM via inhibiting CSC characteristics, in order to expand the research ideas of TCM in combination with targeted therapy.
