Research advances in the mechanism of Toll-like receptor 4 mediated intestinal injury and inflammatory response in necrotizing enterocolitis.
- Author:
Jia WANG
1
;
Cheng CAI
2
,
3
Author Information
1. Department of Neonatology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200062, China.
2. Department of Neonatology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200062, China. *Corresponding author, E-mail: caicheng2004@
3. com.
- Publication Type:English Abstract
- MeSH:
Enterocolitis, Necrotizing/pathology*;
Toll-Like Receptor 4/metabolism*;
Humans;
Infant, Newborn;
Signal Transduction;
Inflammation/metabolism*;
Animals;
Intestines/immunology*;
Intestinal Mucosa/pathology*;
Infant, Premature
- From:
Chinese Journal of Cellular and Molecular Immunology
2025;41(1):57-63
- CountryChina
- Language:Chinese
-
Abstract:
Necrotizing enterocolitis (NEC) is an intestinal inflammatory and necrotic disease seen in premature infants, and remains the leading cause of death resulted from gastrointestinal diseases in premature infants. The specific pathogenesis of NEC is still unclear. In recent years, a lot of studies have reported that Toll-like receptor 4 (TLR4) plays a key role in the pathogenesis of NEC. TLR4, which is abundantly expressed in intestinal epithelial cells of premature infants, binds to bacterial lipopolysaccharide (LPS) to activate downstream signaling pathways, leading to disruption of intestinal epithelial integrity and bacterial translocation, resulting in intestinal ischemic necrosis and inflammatory responses, which may rapidly progress to severe sepsis, multiple organ dysfunction, and death. This paper reviews the mechanism of TLR4-related signaling pathways in intestinal epithelial injury and inflammatory responses in newborns with NEC, providing a reference to study new therapeutic targets for NEC.
